Department of Developmental Behavioral Pediatrics, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Department of Genetic and Metabolism, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Front Endocrinol (Lausanne). 2023 Jul 11;14:1164747. doi: 10.3389/fendo.2023.1164747. eCollection 2023.
This prospective cohort study was aimed at investigating the associations between cord blood metabolic factors and early-childhood growth, further elucidating the relationships between cord blood metabolites and overweight and obesity in early life.
A total of 2,267 pairs of mothers and offspring were recruited in our study. Cord blood plasma was assayed for triglycerides (TGs), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), C-peptide, insulin, and glycosylated hemoglobin type A1C (HbA1c) levels. Data of anthropometric measurements were collected from offspring at birth, 6 months, 12 months, and 18 months. Multiple linear regression models were used to evaluate the correlations between cord blood metabolic factors and weight Z-scores, body mass index (BMI) Z-scores, and weight gains at the early stage of life. Forward stepwise logistic regression analyses were applied to explore the associations between cord blood metabolic factors and early-childhood overweight and obesity. Receiver operating characteristic (ROC) curve analyses were applied to determine the optimal cutoff points for cord blood metabolic factors in predicting early-childhood overweight and obesity.
After adjustments for covariates, cord blood TG concentrations and TG/TC ratios were negatively associated with weight Z-scores from birth to 18 months. Cord blood C-peptide and HbA1c levels were inversely associated with weight Z-scores at 6 months and 18 months. Cord blood TG concentrations and TG/TC ratios were negatively correlated with BMI Z-scores up to 18 months. Cord blood C-peptide levels and HbA1c levels were inversely correlated with BMI Z-scores at 18 months. Cord blood TG, TG/TC ratios, C-peptide, and HbA1c had negative correlations with weight gains from birth to 6 months, but the correlations attenuated as time went on. Increase in cord blood TG and HbA1c levels and TG/TC ratios were significantly associated with decreased risks of overweight and obesity at 6 months, 12 months, and 18 months.
Cord blood metabolic factors were significantly associated with early-childhood growth patterns.
本前瞻性队列研究旨在探讨脐血代谢因子与儿童早期生长的关系，进一步阐明脐血代谢物与生命早期超重和肥胖的关系。
本研究共纳入 2267 对母婴。检测脐血血浆甘油三酯（TGs）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、C 肽、胰岛素和糖化血红蛋白 A1C（HbA1c）水平。在出生、6 个月、12 个月和 18 个月时收集儿童的人体测量学数据。采用多元线性回归模型评估脐血代谢因子与体重 Z 评分、体重指数（BMI）Z 评分和生命早期体重增长的相关性。采用向前逐步逻辑回归分析探讨脐血代谢因子与儿童早期超重和肥胖的关系。采用受试者工作特征（ROC）曲线分析确定脐血代谢因子预测儿童早期超重和肥胖的最佳截断点。
调整协变量后，脐血 TG 浓度和 TG/TC 比值与出生至 18 个月的体重 Z 评分呈负相关。脐血 C 肽和 HbA1c 水平与 6 个月和 18 个月的体重 Z 评分呈负相关。脐血 TG 浓度和 TG/TC 比值与 18 个月时的 BMI Z 评分呈负相关。脐血 C 肽水平和 HbA1c 水平与 18 个月时的 BMI Z 评分呈负相关。脐血 TG、TG/TC 比值、C 肽和 HbA1c 与出生至 6 个月的体重增长呈负相关，但随着时间的推移，相关性减弱。脐血 TG 和 HbA1c 水平以及 TG/TC 比值的增加与 6 个月、12 个月和 18 个月时超重和肥胖风险的降低显著相关。
脐血代谢因子与儿童早期生长模式显著相关。
