叶提取物对大鼠模型中顺铂诱导的肾毒性的改善作用。
Ameliorative Effect of Leaf Extract on Cisplatin-Induced Nephrotoxicity in the Rat Model.
作者信息
Ibrahim Doa'a, Halboup Abdulsalam, Al Ashwal Mohammed, Shamsher Amani
机构信息
Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, University of Science and Technology, Sana'a, Yemen.
Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.
出版信息
Int J Nephrol. 2023 Jul 18;2023:2074498. doi: 10.1155/2023/2074498. eCollection 2023.
BACKGROUND
leaf extract (OELE) has potential health benefits and protects against cytotoxicity. This study investigated the possible ameliorative effect of OELE on cisplatin-induced nephrotoxicity in rats.
METHODS
Rats were assigned into six groups; two groups received 150 mg/kg or 300 mg/kg of OELE, one group received a single dose of cisplatin (6 mg/kg) IP on the first day of the experiment, two groups received a single dose of cisplatin 150 mg/kg or 300 mg/kg of OELE on the first day then starting from the fifth day for 10 consecutive days, and one group acted as a control. . The findings showed that cisplatin-induced nephrotoxicity was evidenced by a significant increase in serum creatinine blood urea nitrogen (BUN) and a significant decrease in estimated creatinine clearance and potassium level, which corresponded with the alterations in the histopathology of the renal tissue. OELE significantly ameliorated the nephrotoxic effects of cisplatin as dose-dependent.
背景
叶提取物（OELE）具有潜在的健康益处，并能预防细胞毒性。本研究调查了OELE对顺铂诱导的大鼠肾毒性可能的改善作用。
方法
将大鼠分为六组；两组分别接受150mg/kg或300mg/kg的OELE，一组在实验第一天腹腔注射单剂量顺铂（6mg/kg），两组在第一天接受单剂量顺铂，同时分别接受150mg/kg或300mg/kg的OELE，然后从第五天开始连续10天给药，一组作为对照。研究结果表明，顺铂诱导的肾毒性表现为血清肌酐、血尿素氮（BUN）显著升高，估计肌酐清除率和钾水平显著降低，这与肾组织病理变化一致。OELE呈剂量依赖性地显著改善了顺铂的肾毒性作用。
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