Januário Beatriz Dias, Mafra Natália Silva, de Souza Silva Humberto, Carvalho Isabella Monteiro, Sena Ana Luiza Sobreira, Pereira Ana Paula Gomes Soares, de Faria Júnior Newton Santos, Campos Helton Oliveira
Departamento de Ciências Biológicas, Universidade do Estado de Minas Gerais - Unidade Carangola, Carangola (MG), 36800- 000, Brasil.
Departamento de Nutrição e Saúde, Universidade Federal de Viçosa, Viçosa (MG), 36570-900, Brasil.
Curr Drug Metab. 2023;24(8):568-586. doi: 10.2174/1389200224666230727093010.
The present study has compiled the prevalence of polypharmacy worldwide and assessed the prevalence of polypharmacy in different populations, including community-dwelling individuals, hospitalized patients, and institutionalized patients.
This systematic review was conducted and reported according to the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement. A systematic search of electronic databases, including PubMed, Web of Science, and Scielo, was performed in March 2021 without any date and language restrictions. Combinations of the following keywords were used for the search strategy: polypharmacy OR multiple medications OR multiple medicines OR multiple drug AND prevalence. Based on the search and inclusion criteria, two hundred and eight studies (73,076,167 individuals) were selected for inclusion in the systematic review. It was observed that there is a wide variation in the prevalence of polypharmacy between studies.
The prevalence of polypharmacy was found to be 30.2%, 61.7%, and 56.9% for community-dwelling individuals, hospitalized patients, and institutionalized patients, respectively.
Based on the analyses, this systematic review has demonstrated a wide variation in the prevalence of polypharmacy between studies and countries and a high prevalence of polypharmacy in institutionalized and hospitalized patients.
本研究汇总了全球多重用药的患病率，并评估了不同人群（包括社区居民、住院患者和机构化照护患者）中多重用药的患病率。
本系统评价按照系统评价和Meta分析的首选报告项目（PRISMA）声明中概述的指南进行并报告。2021年3月对电子数据库进行了系统检索，包括PubMed、科学网和Scielo，检索无任何日期和语言限制。搜索策略使用了以下关键词的组合：多重用药或多种药物或多种药品或多种药物与患病率。根据检索和纳入标准，选择了208项研究（73,076,167人）纳入该系统评价。观察到各研究之间多重用药的患病率存在很大差异。
社区居民、住院患者和机构化照护患者的多重用药患病率分别为30.2%、61.7%和56.9%。
基于分析，本系统评价表明，各研究和国家之间多重用药的患病率存在很大差异，且机构化照护患者和住院患者中多重用药的患病率很高。
