Seem E, Stranden E
Scand J Clin Lab Invest. 1986 Sep;46(5):417-22. doi: 10.3109/00365518609083692.
Starling forces (interstitial fluid pressure, plasma- and interstitial fluid colloid osmotic pressures) were measured in the subcutaneous tissue of legs in 22 patients with deep venous thrombosis (DVT). For comparison, measurements were obtained in the contralateral leg and in healthy controls as well. Interstitial fluid pressure (Pif) was measured with the 'wick-in-needle' technique and we found a significantly higher pressure in limbs with DVT compared to contralateral limbs and controls. Interstitial fluid was collected from subcutaneous tissue with the 'wick technique'. Colloid osmotic pressure was measured in wick interstitial fluid (COPif) and plasma (COPpl) with an osmometer. A significant reduction of COPif was found in limbs with DVT compared to the contralateral side and controls. The COPpl was also significantly reduced in patients compared to controls. Saphenous vein pressure (Pv) measured at the ankle was significantly increased in the thrombosed limb compared to the contralateral. We conclude that the main cause of subcutaneous oedema in DVT of the lower limbs is increased transcapillary filtration caused by a rise in Pv. This leads to a fall in COPif and rise in Pif which act as oedema-preventing mechanisms.
在22例深静脉血栓形成（DVT）患者的腿部皮下组织中测量了Starling力（组织间隙流体压力、血浆和组织间隙流体胶体渗透压）。作为对照，还在对侧腿部和健康对照者中进行了测量。采用“针芯吸液”技术测量组织间隙流体压力（Pif），我们发现与对侧肢体和对照相比，DVT肢体的压力显著更高。采用“吸液技术”从皮下组织收集组织间隙流体。用渗透压计测量吸液组织间隙流体（COPif）和血浆（COPpl）中的胶体渗透压。与对侧和对照相比，DVT肢体的COPif显著降低。与对照相比，患者的COPpl也显著降低。与对侧相比，血栓形成肢体在脚踝处测量的大隐静脉压力（Pv）显著升高。我们得出结论，下肢DVT皮下水肿的主要原因是Pv升高导致的跨毛细血管滤过增加。这导致COPif下降和Pif升高，它们起到了预防水肿的作用。
