Mani M, Schmid J, Genton C, Laissue J A, Musy J P
Schweiz Med Wochenschr. 1986 Jul 26;116(30):1003-8.
Carcinoma develops in about 1-2% of ovarian mature cystic teratomas, usually in postmenopausal women, squamous cell carcinoma being the most common tumor type. This study is based on a review of 300 published and 5 new cases. The carcinomatous tissue tends to invade adjacent organs, whereas lymph node metastasis has rarely been diagnosed. A five-year survival rate of about 15% testifies to the poor prognosis. The treatment of tumors confined to the ovary (stage Ia, Ib; FIGO) usually consists of bilateral oophorectomy and total hysterectomy. Exceptionally, in young women of childbearing age, treatment may be limited to unilateral oophorectomy. A thorough surgical, cytologic and bioptic examination of the abdominal cavity should be done to confirm an early tumor stage. In more advanced stages (FIGO Ic to IV), complete eradication of the malignant tissue offers the only chance of cure. The efficacy of chemo- and radiotherapy has not been studied systematically. We suggest that carcinoma in mature cystic teratoma be staged and treated according to the guidelines established for common epithelial neoplasms of the ovary.
约1%-2%的卵巢成熟囊性畸胎瘤会发生癌变，通常见于绝经后女性，其中鳞状细胞癌是最常见的肿瘤类型。本研究基于对300例已发表病例和5例新病例的回顾。癌组织倾向于侵犯邻近器官，而淋巴结转移很少被诊断出来。约15%的五年生存率表明预后较差。局限于卵巢的肿瘤（FIGO分期Ia、Ib期）的治疗通常包括双侧卵巢切除术和全子宫切除术。例外情况是，对于育龄年轻女性，治疗可能仅限于单侧卵巢切除术。应进行全面的腹腔手术、细胞学和活检检查以确认早期肿瘤分期。在更晚期（FIGO Ic至IV期），彻底清除恶性组织是唯一的治愈机会。化疗和放疗的疗效尚未进行系统研究。我们建议，成熟囊性畸胎瘤中的癌应根据为卵巢常见上皮性肿瘤制定的指南进行分期和治疗。
