Department of Periodontology, Meenakshi Ammal Dental College and Hospital, Chennai, India.
Department of Basic Medical Sciences, Sri Ramachandra Medical College and Research Institute, Chennai, India.
Oral Dis. 2024 May;30(4):2645-2652. doi: 10.1111/odi.14695. Epub 2023 Jul 27.
The aim of this study was to assess and correlate the serum and GCF levels of omentin with the periodontal status of rheumatoid arthritis (RA) patients with and without periodontitis.
Forty-four patients were divided into four groups: group H: 11 systemically and periodontally healthy subjects; group P: 11 systemically healthy subjects with periodontitis; group RA: 11 periodontally healthy subjects with rheumatoid arthritis and group RA + P: 11 rheumatoid arthritis subjects with periodontitis. Periodontal parameters (plaque index, modified gingival index, probing depth, and clinical attachment level) were recorded and serum and GCF samples were collected for the estimation of omentin using ELISA.
The mean value of plaque index, modified gingival index, probing depth, and clinical attachment level were significantly higher whereas serum and GCF omentin levels were found to be decreased in group IV when compared to the other groups. The significant correlation was found between the serum and GCF omentin levels with all the periodontal parameters.
The omentin level in serum and GCF was found to be lower in RA patients with periodontitis. It is also inversely correlated with the periodontal parameters. Thus, omentin can serve as a significant diagnostic and therapeutic tool in both periodontal and rheumatoid disease.
本研究旨在评估和关联血清和龈沟液中网膜素与伴或不伴牙周炎的类风湿关节炎（RA）患者的牙周状况。
将 44 名患者分为四组：H 组：11 名系统和牙周健康的受试者；P 组：11 名系统健康但患有牙周炎的受试者；RA 组：11 名牙周健康但患有类风湿关节炎的受试者；RA+P 组：11 名患有牙周炎和类风湿关节炎的受试者。记录牙周参数（菌斑指数、改良龈炎指数、探诊深度和临床附着水平），并采集血清和龈沟液样本，通过 ELISA 测定网膜素。
与其他组相比，IV 组的菌斑指数、改良龈炎指数、探诊深度和临床附着水平平均值显著升高，而血清和龈沟液网膜素水平则降低。血清和龈沟液网膜素水平与所有牙周参数之间存在显著相关性。
患有牙周炎的 RA 患者的血清和龈沟液中网膜素水平较低，与牙周参数呈负相关。因此，网膜素可以作为牙周病和类风湿病的重要诊断和治疗工具。
