Department of Radiation Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan
Department of Radiation Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Anticancer Res. 2023 Aug;43(8):3571-3577. doi: 10.21873/anticanres.16535.
BACKGROUND/AIM: The purpose of this study was to evaluate the impact of recent radiotherapy on mortality from heart disease in Asians or Pacific islanders with breast cancer using the Surveillance, Epidemiology, and End Results (SEER) database.
Asians or Pacific islanders with stage 0 or I (AJCC 6th) breast cancer between 2000 and 2015 were analyzed. The impact of radiotherapy for mortality from heart disease after treatment was evaluated by comparing patients who received radiotherapy for left-sided breast cancer, patients who received radiotherapy for right-sided breast cancer and patients who did not receive radiotherapy.
In 25,684 Asians or Pacific islanders, the incidence of cardiac death was higher in patients who did not receive radiotherapy than in patients who received radiotherapy. Among patients who received external beam irradiation, the incidence of cardiac death was 2.00% for patients with left-sided breast cancer and 1.69% for patients with right-sided breast cancer, with no significant difference (chi-square test, p=0.427). In the period from 2000 to 2008, there was no significant difference between the cumulative heart-related death rates in patients who received radiotherapy and in patients who did not receive radiotherapy (Tarone-Ware test, p=0.406); however, in 2009-2015, the cumulative heart-related death rate in patients who did not receive radiotherapy was significantly higher than that in patients who received radiotherapy (log-rank test, p<0.001).
Heart-related death after treatment for breast cancer is relatively rare in Asians or Pacific islanders. Since at least 2000, the cardiac impact of postoperative radiotherapy has not been significant.
背景/目的：本研究旨在利用监测、流行病学和最终结果（SEER）数据库评估最近放疗对亚洲或太平洋岛民乳腺癌患者心脏病死亡率的影响。
分析了 2000 年至 2015 年间 0 期或 I 期（AJCC 第 6 版）乳腺癌的亚洲或太平洋岛民患者。通过比较接受左侧乳腺癌放疗的患者、接受右侧乳腺癌放疗的患者和未接受放疗的患者，评估放疗对心脏病死亡率的影响。
在 25684 名亚洲或太平洋岛民患者中，未接受放疗的患者心脏死亡的发生率高于接受放疗的患者。在接受外照射放疗的患者中，左侧乳腺癌患者的心脏死亡发生率为 2.00%，右侧乳腺癌患者的发生率为 1.69%，差异无统计学意义（卡方检验，p=0.427）。在 2000 年至 2008 年期间，接受放疗和未接受放疗的患者的累积心脏相关死亡率之间无显著差异（Tarone-Ware 检验，p=0.406）；然而，在 2009 年至 2015 年期间，未接受放疗的患者的累积心脏相关死亡率明显高于接受放疗的患者（对数秩检验，p<0.001）。
在亚洲或太平洋岛民中，乳腺癌治疗后的心脏相关死亡相对较少。自 2000 年以来，术后放疗对心脏的影响并不显著。
