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1
Kynurenic acid: translational perspectives of a therapeutically targetable gliotransmitter.犬尿喹啉酸：一种具有治疗靶点的神经胶质递质的转化研究前景
Neuropsychopharmacology. 2024 Jan;49(1):307-308. doi: 10.1038/s41386-023-01681-6.
2
Kynurenic acid and zaprinast diminished CXCL17-evoked pain-related behaviour and enhanced morphine analgesia in a mouse neuropathic pain model.犬尿氨酸和扎普司特可减少 CXCL17 诱导的疼痛相关行为，并增强吗啡在小鼠神经病理性疼痛模型中的镇痛作用。
Pharmacol Rep. 2019 Feb;71(1):139-148. doi: 10.1016/j.pharep.2018.10.002. Epub 2018 Oct 6.
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Studies on the metabolism of kynurenic acid. III. Enzymatic formation of 7,8-dihydroxykynurenic acid from kynurenic acid.犬尿喹啉酸的代谢研究。III. 由犬尿喹啉酸酶促形成7,8-二羟基犬尿喹啉酸。
J Biol Chem. 1963 Jan;238:283-93.
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Experimental hypothyroidism raises brain kynurenic acid - Novel aspect of thyroid dysfunction.实验性甲状腺功能减退症会导致脑中犬尿氨酸升高——甲状腺功能障碍的新方面。
Eur J Pharmacol. 2020 Sep 15;883:173363. doi: 10.1016/j.ejphar.2020.173363. Epub 2020 Jul 11.
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The metabolism of kynurenic acid. II. Tracer experiments on the mechanism of kynurenic acid degradation and glutamic acid synthesis by Pseudomonas extracts.犬尿酸的代谢。II. 用示踪实验研究假单胞菌提取物降解犬尿酸及合成谷氨酸的机制
J Biol Chem. 1961 Nov;236:2991-5.
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Fluorometric determination of urinary kynurenic acid by flow injection analysis equipped with a "bypass line".采用配备“旁路管线”的流动注射分析法荧光测定尿中犬尿喹啉酸
Anal Biochem. 1990 Oct;190(1):88-91. doi: 10.1016/0003-2697(90)90138-y.
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Spectrofluorometric determination of kynurenic acid with horseradish peroxidase in the presence of hydrogen peroxide.
Anal Sci. 2007 Mar;23(3):317-20. doi: 10.2116/analsci.23.317.
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Preparation and properties of nanoscale containers for biomedical application in drug delivery: preliminary studies with kynurenic acid.用于药物输送的生物医学应用的纳米容器的制备和性质：初步研究与犬尿氨酸。
J Neural Transm (Vienna). 2012 Feb;119(2):115-21. doi: 10.1007/s00702-011-0726-2. Epub 2011 Nov 8.
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Studies on the metabolism of kynurenic acid. I. The formation of L-glutamic acid, D- and L-alanine, and acetic acid from kynurenic acid by Pseudomonas extracts.犬尿喹啉酸代谢的研究。I. 假单胞菌提取物将犬尿喹啉酸转化为L-谷氨酸、D-和L-丙氨酸以及乙酸的过程。
J Biol Chem. 1961 Sep;236:2492-7.
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Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia.
Neurosci Lett. 2001 Nov 2;313(1-2):96-8. doi: 10.1016/s0304-3940(01)02242-x.

引用本文的文献

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Gut microbiota-mediated pain sensitization: mechanisms and therapeutic implications.肠道微生物群介导的疼痛敏化：机制与治疗意义。
Front Pain Res (Lausanne). 2025 Jul 3;6:1626515. doi: 10.3389/fpain.2025.1626515. eCollection 2025.
2
Kynurenic Acid Synthesis from D-Kynurenine in the Cerebellum: A Distinct Role of D-Amino Acid Oxidase.小脑内由D-犬尿氨酸合成犬尿喹啉酸：D-氨基酸氧化酶的独特作用
Cells. 2025 Jul 5;14(13):1030. doi: 10.3390/cells14131030.
3
Parental kynurenine 3-monooxygenase genotype in mice directs sex-specific behavioral outcomes in offspring.小鼠中亲本犬尿氨酸3-单加氧酶基因型决定后代的性别特异性行为结果。
Biol Sex Differ. 2025 Apr 2;16(1):22. doi: 10.1186/s13293-025-00703-w.
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The Role of Glial Cells in the Pathophysiology of Epilepsy.神经胶质细胞在癫痫病理生理学中的作用。
Cells. 2025 Jan 10;14(2):94. doi: 10.3390/cells14020094.
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Neuroactive Kynurenines as Pharmacological Targets: New Experimental Tools and Exciting Therapeutic Opportunities.神经活性色氨酸代谢产物作为药理学靶点：新的实验工具和令人兴奋的治疗机会。
Pharmacol Rev. 2024 Oct 16;76(6):978-1008. doi: 10.1124/pharmrev.124.000239.
6
Elevated serum kynurenic acid in individuals with first-episode psychosis and insufficient response to antipsychotics.首发精神病患者血清犬尿喹啉酸升高及对抗精神病药物反应不足。
Schizophrenia (Heidelb). 2024 Jul 10;10(1):61. doi: 10.1038/s41537-024-00483-z.
7
Reducing brain kynurenic acid synthesis precludes kynurenine-induced sleep disturbances.降低脑内犬尿酸合成可预防犬尿氨酸诱导的睡眠障碍。
J Sleep Res. 2024 May;33(3):e14038. doi: 10.1111/jsr.14038. Epub 2023 Sep 7.

本文引用的文献

1
Kynurenine aminotransferase II inhibition promotes sleep and rescues impairments induced by neurodevelopmental insult.犬尿氨酸氨基转移酶 II 抑制促进睡眠并挽救神经发育损伤引起的损伤。
Transl Psychiatry. 2023 Mar 31;13(1):106. doi: 10.1038/s41398-023-02399-1.
2
GRK3 deficiency elicits brain immune activation and psychosis.GRK3 缺乏会引起大脑免疫激活和精神病。
Mol Psychiatry. 2021 Nov;26(11):6820-6832. doi: 10.1038/s41380-021-01106-0. Epub 2021 May 12.
3
Dysregulation of kynurenine metabolism is related to proinflammatory cytokines, attention, and prefrontal cortex volume in schizophrenia.色氨酸代谢失调与精神分裂症中的促炎细胞因子、注意力和前额叶皮层体积有关。
Mol Psychiatry. 2020 Nov;25(11):2860-2872. doi: 10.1038/s41380-019-0401-9. Epub 2019 Apr 3.
4
A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder.脑脊液中犬尿喹啉酸的全基因组关联研究：对双相情感障碍中精神病性症状和认知障碍的意义
Mol Psychiatry. 2016 Oct;21(10):1342-50. doi: 10.1038/mp.2015.186. Epub 2015 Dec 15.
5
Kynurenines in the mammalian brain: when physiology meets pathology.哺乳动物大脑中的犬尿氨酸：当生理学遇到病理学。
Nat Rev Neurosci. 2012 Jul;13(7):465-77. doi: 10.1038/nrn3257.

Kynurenic acid: translational perspectives of a therapeutically targetable gliotransmitter.

作者信息

Pocivavsek Ana, Erhardt Sophie

机构信息

Department of Pharmacology, Physiology, and Neuroscience, University of South Carolina School of Medicine, Columbia, SC, USA.

Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.

出版信息

Neuropsychopharmacology. 2024 Jan;49(1):307-308. doi: 10.1038/s41386-023-01681-6.

DOI:10.1038/s41386-023-01681-6
PMID:37500723
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10700309/
Abstract
摘要