Kynurenic acid: translational perspectives of a therapeutically targetable gliotransmitter.
作者信息
Pocivavsek Ana, Erhardt Sophie
机构信息
Department of Pharmacology, Physiology, and Neuroscience, University of South Carolina School of Medicine, Columbia, SC, USA.
Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.
出版信息
Neuropsychopharmacology. 2024 Jan;49(1):307-308. doi: 10.1038/s41386-023-01681-6.
Abstract
摘要
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Transl Psychiatry. 2023 Mar 31;13(1):106. doi: 10.1038/s41398-023-02399-1.
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GRK3 deficiency elicits brain immune activation and psychosis.GRK3 缺乏会引起大脑免疫激活和精神病。
Mol Psychiatry. 2021 Nov;26(11):6820-6832. doi: 10.1038/s41380-021-01106-0. Epub 2021 May 12.
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Dysregulation of kynurenine metabolism is related to proinflammatory cytokines, attention, and prefrontal cortex volume in schizophrenia.色氨酸代谢失调与精神分裂症中的促炎细胞因子、注意力和前额叶皮层体积有关。
Mol Psychiatry. 2020 Nov;25(11):2860-2872. doi: 10.1038/s41380-019-0401-9. Epub 2019 Apr 3.
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A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder.脑脊液中犬尿喹啉酸的全基因组关联研究：对双相情感障碍中精神病性症状和认知障碍的意义
Mol Psychiatry. 2016 Oct;21(10):1342-50. doi: 10.1038/mp.2015.186. Epub 2015 Dec 15.
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Kynurenines in the mammalian brain: when physiology meets pathology.哺乳动物大脑中的犬尿氨酸：当生理学遇到病理学。
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