Department of Medicine, Loma Linda University Health, Loma Linda, CA, USA.
Loma Linda University School of Medicine, Loma Linda, CA, USA.
Prog Transplant. 2023 Sep;33(3):223-228. doi: 10.1177/15269248231189870. Epub 2023 Jul 28.
Expedited liver transplant evaluations of critically ill patients can be challenging due to limited time for data gathering and psychosocial evaluation.
To compare clinical outcomes between expedited and traditional transplant evaluation patients and assess for differences in outpatient resource utilization and staff burden between groups.
Adult liver transplant recipients who underwent transplant from 2015 to 2019 were included. Expedited evaluation was defined as time from initiating transplant evaluation to transplant listing <2 weeks. Primary outcomes included rates of graft rejection, graft failure, and death within 1-year posttransplant. Secondary outcomes included number of acute care visits, office visits, and medical record documentation made by transplant staff within 1-year posttransplant. Outcomes were compared using Cox regression models.
Of the 335 patients included, 92 (27.5%) were expedited and 243 (72.5%) were traditional. Expedited patients were significantly younger, had greater MELD scores, and required more inpatient care and life support at time of transplant. There was no significant difference in risk of graft rejection (HR 1.3, = .4), graft failure (HR 1.3, = .6), or mortality (HR 1.0, = .9) between groups. Expedited transplant was not associated with increased healthcare or staff utilization: acute care visits (rate ratio 0.9, = .7), office visits (β = -1.05, = .2), and medical record documentation (β = 3.4, = 0.4).
Despite being more critically ill, patients requiring expedited transplant evaluation have favorable outcomes after transplant and do not require more intensive staff time and resources compared to traditional candidates.
由于收集数据和心理社会评估的时间有限,对危重症患者进行快速肝移植评估具有挑战性。
比较快速和传统肝移植评估患者的临床结果,并评估两组之间门诊资源利用和工作人员负担的差异。
纳入 2015 年至 2019 年接受肝移植的成年肝移植受者。快速评估定义为从开始移植评估到移植列表的时间<2 周。主要结局包括移植后 1 年内移植物排斥、移植物衰竭和死亡的发生率。次要结局包括移植后 1 年内移植工作人员进行的急性护理就诊、就诊次数和病历记录数量。使用 Cox 回归模型比较结果。
在纳入的 335 例患者中,92 例(27.5%)为快速评估,243 例(72.5%)为传统评估。快速评估患者明显更年轻,MELD 评分更高,移植时需要更多的住院治疗和生命支持。两组之间移植物排斥(HR 1.3, = .4)、移植物衰竭(HR 1.3, = .6)或死亡率(HR 1.0, = .9)的风险无显著差异。快速移植与增加的医疗保健或工作人员利用率无关:急性护理就诊(率比 0.9, = .7)、就诊次数(β=-1.05, = .2)和病历记录(β=3.4, = 0.4)。
尽管病情更危急,但需要快速移植评估的患者在移植后结果良好,与传统候选者相比,并不需要更多的密集工作人员时间和资源。