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70岁及以上患者动脉瘤性蛛网膜下腔出血的血管内治疗与显微手术治疗的疗效比较

Outcomes of Endovascular Therapy versus Microsurgical Treatment for Aneurysmal Subarachnoid Hemorrhage in Patients ≥70 Years of Age.

作者信息

Akiyama Ryo, Imamura Hirotoshi, Tani Shoichi, Adachi Hidemitsu, Fukumitsu Ryu, Sunohara Tadashi, Omura Yoshihiro, Funakoshi Yusuke, Matsui Yuichi, Sasaki Natsuhi, Fukuda Tatsumaru, Horiuchi Kazufumi, Kajiura Shinji, Shigeyasu Masashi, Sakai Nobuyuki

机构信息

Department of Neurosurgery, Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan.

出版信息

J Neuroendovasc Ther. 2020;14(1):1-7. doi: 10.5797/jnet.oa.2019-0092. Epub 2019 Nov 29.

Abstract

PURPOSE

This retrospective research aimed to compare the efficacy of endovascular therapy (EVT) versus microsurgical treatment (MST) for elderly patients with aneurysmal subarachnoid hemorrhage (aSAH).

METHODS

Elderly (>70 years) patients with aSAH who underwent aneurysm obliteration during 2007-2017 were selected from our hospital database and enrolled in this retrospective study. We reviewed each patient's background, the severity of the aSAH, and aneurysmal characteristics that compelled EVT or microsurgery treatment and then compared the two treatment groups. A favorable primary outcome was defined by a modified Rankin scale (mRS) score of 0-3 at hospital discharge. The 78 patients formed two cohorts (39 patients each) based on their propensity scores for EVT or MST. We estimated the adjusted odds ratio, followed by a sensitivity analysis of the original 201 patients (118 with EVT and 83 with MST).

RESULTS

In the propensity score-matched cohorts, favorable outcomes were observed in 33.3% and 7.7% of patients in the EVT and MST groups, respectively (p = 0.01). Results of the sensitivity analysis were similar to the main results.

CONCLUSION

The clinical outcomes for the elderly aSAH patients were better in the EVT group than in MST group.

摘要

目的

本回顾性研究旨在比较血管内治疗(EVT)与显微手术治疗(MST)对老年动脉瘤性蛛网膜下腔出血(aSAH)患者的疗效。

方法

从我院数据库中选取2007年至2017年期间接受动脉瘤闭塞治疗的老年(>70岁)aSAH患者,并纳入本回顾性研究。我们回顾了每位患者的背景、aSAH的严重程度以及促使采用EVT或显微手术治疗的动脉瘤特征,然后比较两个治疗组。出院时改良Rankin量表(mRS)评分为0-3被定义为良好的主要结局。根据78例患者接受EVT或MST的倾向评分,将其分为两个队列(各39例)。我们估计了调整后的优势比,随后对最初的201例患者(118例接受EVT,83例接受MST)进行了敏感性分析。

结果

在倾向评分匹配队列中,EVT组和MST组分别有33.3%和7.7%的患者获得了良好结局(p=0.01)。敏感性分析结果与主要结果相似。

结论

老年aSAH患者接受EVT治疗的临床结局优于MST组。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6abe/10370813/0a917045ff8d/jnet-14-01-g001.jpg

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