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经肛门冲洗治疗肠道功能障碍的长期疗效

Long-Term Outcomes of Transanal Irrigation for Bowel Dysfunction.

作者信息

Tamvakeras Panagiotis, Horrobin Clare, Chang Jessica, Chapman Mark

机构信息

Colorectal Surgery, University Hospitals Birmingham NHS Foundation Trust, The Royal Town of Sutton Coldfield, GBR.

Lower GI Physiology, University Hospitals Birmingham NHS Foundation Trust, The Royal Town of Sutton Coldfield, GBR.

出版信息

Cureus. 2023 Jul 26;15(7):e42507. doi: 10.7759/cureus.42507. eCollection 2023 Jul.

Abstract

INTRODUCTION

Transanal irrigation (TAI) improves bowel function and quality of life in patients with neurogenic bowel disease compared to conservative bowel care. Its use has been extended to a range of defecatory disorders. However, data on long-term benefits and compliance are lacking. We aim to evaluate the long-term efficacy of TAI by examining compliance and patient outcomes over a five-year period.

METHODS

This study is a five-year retrospective review of patients practising TAI in a district general hospital. Patient demographics, indications, long-term compliance, adverse events, and patient-reported Qufora bowel symptom bother scores were analysed.

RESULTS

A cohort of 18 patients had a median age of 61 (range 23-91) and were predominantly female (83.5%). The reasons for bowel dysfunction were diverse: low anterior resection syndrome, neurogenic bowel, congenital anorectal malformations, obstructed defecation, and functional disorders. Predominant symptoms were constipation (9), faecal incontinence (7), and mixed (2). Both high-volume (catheter and cone) and low-volume (mini cone) irrigation devices were used. Fourteen patients continued regular irrigation at a median follow-up of 27.7 months (range 5.1-72.3), while four had discontinued at a median follow-up of 4.8 months. The reasons for discontinuation were inadequate rectal evacuation and spontaneous improvement of symptoms. In the compliant group, there was a significant improvement in bowel symptom scores (p=0.003). No major adverse events, such as significant rectal bleeding or perforation, were noted.

CONCLUSION

In this small cohort, TAI was safe and effective for long-term use; however, a fifth of patients discontinued treatment. Further work needs to be done to identify those patients who will benefit from TAI.

摘要

引言

与保守的肠道护理相比,经肛门灌洗(TAI)可改善神经源性肠道疾病患者的肠道功能和生活质量。其应用已扩展到一系列排便障碍。然而,缺乏关于长期益处和依从性的数据。我们旨在通过检查五年期间的依从性和患者结果来评估TAI的长期疗效。

方法

本研究是对一家地区综合医院中进行TAI治疗的患者进行的为期五年的回顾性研究。分析了患者的人口统计学资料、适应症、长期依从性、不良事件以及患者报告的Qufora肠道症状困扰评分。

结果

18例患者的队列中位年龄为61岁(范围23 - 91岁),且以女性为主(83.5%)。肠道功能障碍的原因多种多样:低位前切除综合征、神经源性肠道、先天性肛门直肠畸形、排便梗阻和功能性障碍。主要症状为便秘(9例)、大便失禁(7例)和混合型(2例)。使用了大容量(导管和锥形)和小容量(微型锥形)灌洗装置。14例患者在中位随访27.7个月(范围5.1 - 72.3个月)时继续定期灌洗,而4例患者在中位随访4.8个月时停止灌洗。停止灌洗的原因是直肠排空不足和症状自发改善。在依从性组中,肠道症状评分有显著改善(p = 0.003)。未观察到重大不良事件,如严重直肠出血或穿孔。

结论

在这个小队列中,TAI长期使用安全有效;然而,五分之一的患者停止了治疗。需要进一步开展工作以确定那些将从TAI中获益的患者。

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本文引用的文献

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