Department of Operating Room, The Third People's Hospital of Chengdu, Chengdu, China.
The Center of Gastrointestinal and Minimally Invasive Surgery, The Third People's Hospital of Chengdu, Chengdu, China.
Front Immunol. 2023 Jul 12;14:1201167. doi: 10.3389/fimmu.2023.1201167. eCollection 2023.
Existing cross-sectional and retrospective studies were unable to establish a causal relationship between psoriasis and cutaneous melanoma (CM). We sought to evaluate the causal role between psoriasis and CM.
We performed a bidirectional two-sample Mendelian randomization analysis using summary statistics from genome-wide association studies of psoriasis and CM among individuals of predominantly European ancestry. Mendelian randomization-Egger regression, inverse variance weighting, Mendelian Randomization Pleiotropy RESidual Sum and Outlier, weighted mode, and weighted median were used to examine the causal effect between psoriasis and CM.
Genetically predicted psoriasis was a significant risk factor for CM (odds ratio, 1.69; 95% confidence interval, 1.15-2.48; P = 0.025). In contrast, no association was observed between genetically predicted CM and psoriasis.
Our findings corroborated the existence of genetically predicted psoriasis increases risk of CM. Enhanced early screening of cutaneous melanoma in patients with psoriasis may improve clinical burden. However, we did not find evidence for a causal link from CM to psoriasis, so further studies are required to elucidate the effect of CM activity on psoriasis.
现有的横断面和回顾性研究未能确定银屑病和皮肤黑色素瘤（CM）之间存在因果关系。我们试图评估银屑病和 CM 之间的因果关系。
我们使用欧洲血统个体的银屑病和 CM 的全基因组关联研究的汇总统计数据，进行了双向两样本孟德尔随机化分析。孟德尔随机化- Egger 回归、逆方差加权、孟德尔随机化多效性残余和异常值、加权模式和加权中位数用于检验银屑病和 CM 之间的因果关系。
遗传预测的银屑病是 CM 的显著危险因素（优势比，1.69；95%置信区间，1.15-2.48；P=0.025）。相比之下，遗传预测的 CM 与银屑病之间没有关联。
我们的研究结果证实了遗传预测的银屑病增加了 CM 的风险。增强对银屑病患者皮肤黑色素瘤的早期筛查可能会降低临床负担。然而，我们没有发现 CM 与银屑病之间存在因果关系的证据，因此需要进一步的研究来阐明 CM 活动对银屑病的影响。
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