Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Department of Dermatology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, China.
J Dermatolog Treat. 2023 Dec;34(1):2240455. doi: 10.1080/09546634.2023.2240455.
Acne vulgaris (AV) is a common skin disease. Fire needle is a method of quickly piercing the local skin lesions with red-hot needles for AV. This work aimed to evaluate the efficacy and safety of fire needle combined with chemical peels for AV.
Eight databases including PubMed, EMBASE, Cochrane Library, Web of Science, China National Knowledge Internet, Wanfang, Sinomed, and VIP databases were searched to enrolled randomized controlled trials (RCTs) comparing fire needle therapy combined with chemical peels with chemical peels alone. The risk of bias was evaluated by the Cochrane Collaboration's tool. Statistical analysis was completed by RevMan 5.3 and Stata 14.0.
Altogether 18 studies including 1213 patients were enrolled. Compared with chemical peels alone, fire needle adjuvant chemical peels therapy improved the total effective rate (RR = 1.37,95% CI [1.26,1.48], < 0.00001) and skin lesions (MD = -2.11, 95% CI [-2.74, -1.47], < 0.00001), and reduced the recurrence rate (RR = 0.50,95% CI [0.33,0.76], = 0.0009).The application of fire needle was associated with few adverse reactions, all of which were well tolerated and transient.
Fire needle adjuvant chemical peels therapy is effective and safe for AV. Nevertheless, more large-scale, well-designed clinical studies are warranted to provide evidence-based medical support.
寻常痤疮（AV）是一种常见的皮肤病。火针是一种用烧红的针迅速刺破局部皮肤病变的方法，用于治疗 AV。本研究旨在评估火针联合化学焕肤治疗 AV 的疗效和安全性。
检索了 PubMed、EMBASE、Cochrane 图书馆、Web of Science、中国知网、万方、中国生物医学文献服务系统和维普数据库等 8 个数据库，纳入比较火针联合化学焕肤与单纯化学焕肤治疗 AV 的随机对照试验（RCT）。采用 Cochrane 协作偏倚风险评估工具评估偏倚风险。采用 RevMan 5.3 和 Stata 14.0 进行统计分析。
共纳入 18 项研究，共 1213 例患者。与单纯化学焕肤相比，火针辅助化学焕肤疗法可提高总有效率（RR=1.37，95%CI[1.26,1.48]， < 0.00001）和皮损改善率（MD=-2.11，95%CI[-2.74, -1.47]， < 0.00001），降低复发率（RR=0.50，95%CI[0.33,0.76]， = 0.0009）。火针的应用不良反应较少，均能耐受且为一过性。
火针联合化学焕肤治疗 AV 有效且安全。然而，需要更多大规模、精心设计的临床试验来提供循证医学支持。
