Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.
Beijing Key Laboratory of Evaluation of Rational Drug Use, Beijing, 100038, China.
Pharmacogenomics. 2023 Jun;24(8):459-474. doi: 10.2217/pgs-2023-0054. Epub 2023 Jul 28.
Examining the association between alleles and different carbamazepine (CBZ)-induced cutaneous adverse reactions in the Chinese population. A systematic review and meta-analysis of case-control studies was conducted. A systematic search was conducted of PubMed, Embase, the Cochrane Library, National Knowledge Infrastructure, the Chinese Biomedical Literature database and Wanfang Digital Periodicals. 23 studies with a total of 1174 patients were included. In the Han population, is significantly associated with the increased risk of CBZ-related Stevens-Johnson syndrome/toxic epidermal necrolysis, and this correlation was not related to geographic distribution. , are associated with CBZ-related maculopapular eruption in South Han population. is associated with CBZ-DRESS in Taiwan Han population. and genes were found to be involved in the occurrence of CBZ cutaneous adverse reactions in Han Chinese.
探讨中国人群中 等位基因与不同卡马西平（CBZ）诱导的皮肤不良反应之间的关系。对病例对照研究进行了系统评价和荟萃分析。系统检索了 PubMed、Embase、Cochrane 图书馆、中国知网、中国生物医学文献数据库和万方数字化期刊。共纳入 23 项研究，共计 1174 例患者。在汉族人群中，与 CBZ 相关的史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症风险增加显著相关，这种相关性与地理分布无关。在南方汉族人群中，与 CBZ 相关的斑丘疹性皮疹相关。在台湾汉族人群中，与 CBZ-DRESS 相关。研究发现， 基因和 基因与汉族人群中 CBZ 皮肤不良反应的发生有关。
