Lee Woojoo, Shin Mi Yeong, Go Eunbyeul, Lim Hyun-Cheol, Jeon Ji-Yoon, Kwon Yerim, Lee Yerin, Kim Tong-Soo, Lee Sung-Keun, Bahk Young Yil
Department of Public Health Science, Graduate School of Public Health, Seoul National University, Seoul, Korea.
Department of Health Research, Jeollanam-do Institute of Health and Environment, Muan, Korea.
Infect Chemother. 2023 Sep;55(3):368-376. doi: 10.3947/ic.2023.0026. Epub 2023 Jun 14.
Although an effective vaccine has been available, measles still causes mast morbidity and mortality world widely. In Korea, a small number of measles cases have been reported through exposure to imported cases among young people with vaccine-induced measles immunity. Recently due to international migration including marriage, marriage migrants were the second-largest group of foreign population in Korea. Our study was carried out to obtain positive rate of measles antibody among married immigrant women from 12 countries in 10 Gun-Counties and 6 Cities, Korea.
A total of 547 blood samples were collected from maternal multicultural members from 12 countries. The measles-specific IgG antibody was measured by ELISA (Enzyme-linked immunosorbent assay; Enzygnost Anti-measles virus/IgG, Siemens Healthcare Diagnostics Products GmbH, Marburg, Germany). We performed a simple logistic regression to test whether the measles antibody seroprevalence differed by participant age, location, or country of birth and then calculated the likelihood ratio statistics to determine whether measles antibody seroprevalence differed by country of birth.
Overall positive measles seroprevalence was 75.3% (95% confidence interval: 71.7 - 78.9). Participants aged 20 - 24 years, 25 - 29 years, and 30 - 63 years has respective seropositivities of 52.5%, 55.3%, and 82.7%. In this study, the geometric mean titers of participants aged 21 - 29 years were slightly lower than those of participants aged over 30 years, which were 1,372 mIU/ml and 2,261 mIU/ml, respectively (average of total participants: 2,027 mIU/ml).
The study provides detailed information about seroimmunity of the married immigrant population in Korea, which is important for measles elimination. Since the 1980s, most vaccine-preventable diseases including measles have been well-controlled. Nevertheless, sporadic measles outbreaks are still reported. Thus, special attention should be paid to the possible importation of infectious diseases such as measles by immigration.
尽管已有有效的疫苗，但麻疹在全球范围内仍导致大量发病和死亡。在韩国，有少数麻疹病例报告是通过接触疫苗诱导的麻疹免疫的年轻人中的输入性病例。最近，由于包括婚姻在内的国际移民，婚姻移民是韩国第二大外国人群体。我们开展这项研究以获取韩国10个郡和6个市来自12个国家的已婚移民妇女中麻疹抗体的阳性率。
共从来自12个国家的多元文化孕产妇成员中采集了547份血样。采用酶联免疫吸附测定法（ELISA；酶联免疫吸附测定；Enzygnost抗麻疹病毒/IgG，德国马尔堡西门子医疗诊断产品有限公司）检测麻疹特异性IgG抗体。我们进行了简单的逻辑回归分析，以检验麻疹抗体血清阳性率是否因参与者年龄、地点或出生国家而异，然后计算似然比统计量，以确定麻疹抗体血清阳性率是否因出生国家而异。
麻疹血清总体阳性率为75.3%（95%置信区间：71.7 - 78.9）。20 - 24岁、25 - 29岁和30 - 63岁的参与者血清阳性率分别为52.5%、55.3%和82.7%。在本研究中，21 - 29岁参与者的几何平均滴度略低于30岁以上参与者，分别为1372 mIU/ml和2261 mIU/ml（所有参与者的平均值：2027 mIU/ml）。
该研究提供了有关韩国已婚移民人群血清免疫的详细信息，这对消除麻疹很重要。自20世纪80年代以来，包括麻疹在内的大多数疫苗可预防疾病已得到很好的控制。然而，仍有散发性麻疹疫情报告。因此，应特别关注移民可能输入的传染病，如麻疹。
