Pradhan Somen K, Panda Ashutosh, Debata Ipsita, Panda Prem S
Department of Community Medicine, Maharaja Krishna Chandra Gajapati Medical College & Hospital, Brahmapur, IND.
Department of Community Medicine, Kalinga Institute of Medical Sciences, Bhubaneswar, IND.
Cureus. 2024 Nov 22;16(11):e74243. doi: 10.7759/cureus.74243. eCollection 2024 Nov.
Incomplete or interrupted vaccination schedules put migrant communities at higher risk for measles, which remains a serious public health concern. The objective of this systematic review was to evaluate the pooled seroprevalence of measles antibodies among migrant groups globally and offer data to guide public health initiatives. Our literature search included PubMed, Scopus, and Embase databases, covering publications from 1990 to 2023, and was systematically refined using specific inclusion and exclusion criteria. Only observational studies documenting measles antibody seroprevalence among defined migrant groups were included to ensure relevance and quality in addressing the study's objective. Meta-analytical techniques such as random-effects models were employed to assess pooled seroprevalence. The meta-analysis comprised 36 studies with 42,972 participants in total. Among migrant communities, the overall pooled seroprevalence of measles antibodies was 83% (95%CI: 80%-87%). Studies showed significant heterogeneity (I = 98%, p < 0.01). According to meta-regression analysis, measles seroprevalence has been gradually increasing in more recent research, and time (year) was a significant predictor of seroprevalence variability (p < 0.05). Measles seroprevalence in migratory communities is still below the threshold for herd immunity, especially in susceptible populations like children and refugees. To close these immunity gaps and stop future outbreaks in host nations, focused public health interventions such as catch-up vaccination programs are desperately needed.
不完整或中断的疫苗接种计划使移民社区面临更高的麻疹风险，麻疹仍然是一个严重的公共卫生问题。本系统评价的目的是评估全球移民群体中麻疹抗体的合并血清阳性率，并提供数据以指导公共卫生举措。我们的文献检索包括PubMed、Scopus和Embase数据库，涵盖1990年至2023年的出版物，并使用特定的纳入和排除标准进行系统筛选。仅纳入记录特定移民群体中麻疹抗体血清阳性率的观察性研究，以确保在解决研究目标方面的相关性和质量。采用随机效应模型等荟萃分析技术来评估合并血清阳性率。荟萃分析包括36项研究，共有42972名参与者。在移民社区中，麻疹抗体的总体合并血清阳性率为83%（95%CI：80%-87%）。研究显示存在显著异质性（I² = 98%，p < 0.01）。根据荟萃回归分析，在最近的研究中麻疹血清阳性率一直在逐渐上升，时间（年份）是血清阳性率变异性的一个显著预测因素（p < 0.05）。移民社区中的麻疹血清阳性率仍低于群体免疫阈值，尤其是在儿童和难民等易感人群中。为了缩小这些免疫差距并防止东道国未来爆发疫情，迫切需要开展诸如补种疫苗计划等有针对性的公共卫生干预措施。
