miR-100 rs1834306 基因 a>g 多态性降低中国儿童神经母细胞瘤发病风险。

miR-100 rs1834306 a > G polymorphism decreases neuroblastoma risk in Chinese children.

机构信息

Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, Guangdong, China.

Department of Pathology, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

出版信息

Cancer Rep (Hoboken). 2023 Oct;6(10):e1875. doi: 10.1002/cnr2.1875. Epub 2023 Jul 28.

DOI:10.1002/cnr2.1875

PMID:37503828

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10598254/

Abstract

BACKGROUND

Neuroblastoma is a common malignant tumor stemming from the sympathetic nervous system in children, which is often life-threatening. The genetics of neuroblastoma remains unclear. Studies have shown that miRNAs participate in the regulation of a broad spectrum of biological pathways. The abnormity in the miRNA is associated with the risk of various cancers, including neuroblastoma. However, research on the relationship of miRNA polymorphisms with neuroblastoma susceptibility is still in the initial stage.

METHODS

In this research, a retrospective case-control study was conducted to explore whether miR-100 rs1834306 A > G polymorphism is associated with neuroblastoma susceptibility. We enrolled 402 cases and 473 controls for the study. The logistic regression analysis was adopted to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between miR-100 rs1834306 A > G and neuroblastoma risk.

RESULTS

Our results elucidated that the miR-100 rs1834306 A > G polymorphism was associated with the decreased risk of neuroblastoma (AG versus AA: adjusted OR = 0.72, 95% CI = 0.53-0.98, and P = 0.038). The subsequent stratified analysis further found that rs1834306 AG/GG genotype reduced the risk of neuroblastoma in the subgroup with tumors of the mediastinum origin (adjusted OR = 0.63, 95% CI = 0.41-0.95, and P = 0.029).

CONCLUSIONS

In summary, miR-100 rs1834306 A > G polymorphism was shown to associate with decreased neuroblastoma risk in Chinese children, especially for neuroblastoma of mediastinum origin. This conclusion needs to be verified in additional large-size case-control studies.

摘要

背景

神经母细胞瘤是一种常见的儿童恶性肿瘤，起源于交感神经系统，常危及生命。神经母细胞瘤的遗传学仍不清楚。研究表明，miRNA 参与广泛的生物途径的调节。miRNA 的异常与包括神经母细胞瘤在内的各种癌症的风险相关。然而，miRNA 多态性与神经母细胞瘤易感性的关系研究仍处于初始阶段。

方法

本研究采用回顾性病例对照研究，探讨 miR-100 rs1834306 A>G 多态性是否与神经母细胞瘤易感性相关。我们共纳入 402 例病例和 473 例对照。采用 logistic 回归分析计算 miR-100 rs1834306 A>G 与神经母细胞瘤风险之间的比值比（OR）及其 95%置信区间（CI）。

结果

研究结果表明，miR-100 rs1834306 A>G 多态性与神经母细胞瘤风险降低相关（AG 与 AA：调整 OR=0.72，95%CI=0.53-0.98，P=0.038）。进一步的分层分析发现，rs1834306 AG/GG 基因型降低了纵隔起源肿瘤亚组的神经母细胞瘤风险（调整 OR=0.63，95%CI=0.41-0.95，P=0.029）。