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聚合物涂覆刻蚀长周期光纤光栅的生物传感，工作在模式转换和折返点附近。

Biosensing by Polymer-Coated Etched Long-Period Fiber Gratings Working near Mode Transition and Turn-around Point.

机构信息

Central Glass and Ceramic Research Institute, CSIR-CGCRI, 196 Raja S C Mullick Road, Kolkata 700032, India.

Istituto di Fisica Applicata "Nello Carrara", CNR-IFAC, Via Madonna del Piano 10, 50019 Sesto Fiorentino, Italy.

出版信息

Biosensors (Basel). 2023 Jul 13;13(7):731. doi: 10.3390/bios13070731.

DOI:10.3390/bios13070731
PMID:37504129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10377345/
Abstract

A methodology to enhance the sensitivity of long-period fiber gratings (LPFGs) based on the combination of three different enhancement approaches is presented; the methods here adopted are the working near mode transition (MT) of a cladding mode (CM), working near the turn-around point of a CM and the enhancement of the evanescent field of CMs by reducing the cladding diameter or by increasing the order number of CMs. In order to combine these enhancement methodologies, an electrostatic self-assembly (ESA) process was used to deposit a polymeric overlay, with a chosen thickness, onto the etched fiber. The add-layer sensitivity of the sensor was theoretically calculated, and the demonstration of the real applicability of the developed LPFG as a biosensor was performed by means of an IgG/anti-IgG immunoassay in human serum in a thermostated microfluidic system. The limits of detection (LODs) calculated by following different procedures (three times the standard deviation of the blank and the mean value of the residuals) were 6.9 × 10 µg/mL and 4.5 × 10 µg/mL, respectively. The calculated LODs demonstrate the effectiveness of the applied methodology for sensitivity enhancement.

摘要

提出了一种基于三种不同增强方法结合的长周期光纤光栅（LPFG）灵敏度增强方法；这里采用的方法是包层模式（CM）的工作近模式转换（MT）、工作在 CM 的转折点附近以及通过减小包层直径或增加 CM 的阶数来增强 CM 的消逝场。为了结合这些增强方法，采用静电自组装（ESA）工艺将具有选定厚度的聚合物覆盖层沉积到蚀刻光纤上。理论上计算了传感器的附加层灵敏度，并通过在恒温微流控系统中用人血清进行 IgG/抗 IgG 免疫测定，演示了所开发的 LPFG 作为生物传感器的实际适用性。通过以下不同程序（空白的三倍标准偏差和残差的平均值）计算的检测限（LOD）分别为 6.9×10μg/ml 和 4.5×10μg/ml。计算出的 LOD 证明了所应用的灵敏度增强方法的有效性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/261c/10377345/7aa46409dc42/biosensors-13-00731-g011.jpg
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本文引用的文献

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Immunosensing Based on Optical Fiber Technology: Recent Advances.基于光纤技术的免疫传感：最新进展。
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Label-free detection of Staphylococcus aureus bacteria using long-period fiber gratings with functional polyelectrolyte coatings.基于功能化聚电解质涂层的长周期光纤光栅无标记检测金黄色葡萄球菌
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