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使用纳米晶羟基磷灰石和可注射富血小板纤维蛋白组合保存牙槽骨：大鼠研究

Alveolar Bone Preservation Using a Combination of Nanocrystalline Hydroxyapatite and Injectable Platelet-Rich Fibrin: A Study in Rats.

作者信息

Pascawinata Andries, Revilla Gusti, Sahputra Roni Eka, Arief Syukri

机构信息

Doctoral Student of Biomedical, Faculty of Medicine, Andalas University, Padang 25163, Indonesia.

Department of Anatomy, Faculty of Medicine, Andalas University, Padang 25163, Indonesia.

出版信息

Curr Issues Mol Biol. 2023 Jul 17;45(7):5967-5980. doi: 10.3390/cimb45070377.

DOI:10.3390/cimb45070377
PMID:37504293
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10377839/
Abstract

Alveolar bone resorption is a post-extraction complication wherein there is a reduction in the dimensions and quality of the alveolar bone. This study aimed to examine the effects of implantation of a combination of nanocrystalline hydroxyapatite (nHA) and injectable platelet-rich fibrin (IPRF) on the expression of tartrate-resistant acid phosphatase (TRAP), alkaline phosphatase (ALP), osteocalcin (OCN), and new bone formation. A total of 32 male rats had their upper right incisors extracted under general anesthesia and were then divided into a control group, nHA group, IPRF group, and nHA-IPRF group. Decapitation was carried out on day 14 and day 28 in each group and the jaws of each rat were subjected to immunohistochemical and histological analysis. The results showed a decrease in TRAP expression in the nHA-IPRF group compared with the control group on day 14 ( = 0.074) and day 28 ( = 0.017). The study also showed an increase in ALP and OCN in the HA-IPRF group on day 14 and day 28 compared with the control group. New bone formation suggested a significant increase in the nHA-IPRF group compared with the control group on day 14 ( = 0.001) and day 28 ( = 0.001). nHA-IPRF implantation can suppress alveolar bone resorption, which is indicated by decreased TRAP expression, and it can increase bone growth, as indicated by increased expression of ALP, OCN, and new bone formation.

摘要

牙槽骨吸收是一种拔牙后并发症，表现为牙槽骨的尺寸和质量降低。本研究旨在探讨纳米晶羟基磷灰石（nHA）与可注射富血小板纤维蛋白（IPRF）联合植入对抗酒石酸酸性磷酸酶（TRAP）、碱性磷酸酶（ALP）、骨钙素（OCN）表达及新骨形成的影响。总共32只雄性大鼠在全身麻醉下拔除右上切牙，然后分为对照组、nHA组、IPRF组和nHA-IPRF组。每组分别在第14天和第28天进行断头处理，对每只大鼠的颌骨进行免疫组织化学和组织学分析。结果显示，与对照组相比，nHA-IPRF组在第14天（P = 0.074）和第28天（P = 0.017）TRAP表达降低。研究还表明，与对照组相比，HA-IPRF组在第14天和第28天ALP和OCN增加。新骨形成显示，与对照组相比，nHA-IPRF组在第14天（P = 0.001）和第28天（P = 0.001）显著增加。nHA-IPRF植入可抑制牙槽骨吸收，表现为TRAP表达降低，并且可增加骨生长，表现为ALP、OCN表达增加和新骨形成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9304/10377839/1eee7d13598e/cimb-45-00377-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9304/10377839/bea635690672/cimb-45-00377-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9304/10377839/9c36c8a784ef/cimb-45-00377-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9304/10377839/f15f3042c37a/cimb-45-00377-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9304/10377839/1eee7d13598e/cimb-45-00377-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9304/10377839/bea635690672/cimb-45-00377-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9304/10377839/9b072b643b04/cimb-45-00377-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9304/10377839/e02726b04cc1/cimb-45-00377-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9304/10377839/fee6c9dda4da/cimb-45-00377-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9304/10377839/185e5fd04994/cimb-45-00377-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9304/10377839/f56750a12fe2/cimb-45-00377-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9304/10377839/9c36c8a784ef/cimb-45-00377-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9304/10377839/f15f3042c37a/cimb-45-00377-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9304/10377839/1eee7d13598e/cimb-45-00377-g010.jpg

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