JDC Healthcare, Houston, TX 77015, USA.
Houston Methodist Hospital, Houston, TX 77030, USA.
Curr Oncol. 2023 Jul 11;30(7):6634-6647. doi: 10.3390/curroncol30070487.
Non-melanoma skin cancer of the head and neck (NMSCHN) is one of the most common malignancies worldwide, and its incidence is growing at a significant rate. It has been found to be aggressive in its spread and has the capacity to metastasize to regional lymph nodes. Cutaneous squamous cell carcinoma (cSCC) has a considerably high mortality rate. It has remarkable characteristics: diameter >2 cm, depth >5 mm, high recurrence, perineural invasion, and locoregional metastases. Aggressive cSCC lesions most commonly metastasize to the parotid gland. Also, immunocompromised patients have a higher risk of developing this aggressive cancer along with the worst prognostic outcomes. It is very important to discuss and assess the risk factors, prognostic factors, and outcomes of patients with cSCC, which will give clinicians future directives for making modifications to their treatment plans. The successful treatment of aggressive cSCC of the head and neck includes early detection and diagnosis, surgery alone or adjuvant chemotherapy, and radiotherapy as required. Multimodal therapy options should be considered by clinicians for better outcomes of aggressive cSCC of the head and neck.
头颈部非黑色素瘤皮肤癌（NMSCHN）是全球最常见的恶性肿瘤之一，其发病率呈显著增长趋势。研究发现，它具有侵袭性的扩散能力，并能转移到局部淋巴结。皮肤鳞状细胞癌（cSCC）的死亡率相当高。它具有显著的特征：直径>2cm，深度>5mm，高复发，神经周围侵犯和局部区域转移。侵袭性 cSCC 病变最常见于转移到腮腺。此外，免疫功能低下的患者发生这种侵袭性癌症的风险更高，预后最差。讨论和评估 cSCC 患者的风险因素、预后因素和结果非常重要，这将为临床医生提供未来修改治疗计划的指导。头颈部侵袭性 cSCC 的成功治疗包括早期发现和诊断、单独手术或辅助化疗以及必要时的放疗。临床医生应考虑采用多模式治疗选择，以获得更好的头颈部侵袭性 cSCC 结果。
