Department of Oncology, Odense University Hospital, 5000 Odense, Denmark.
Department of Clinical Research, University of Southern Denmark, 5000 Odense, Denmark.
Curr Oncol. 2023 Jul 18;30(7):6820-6837. doi: 10.3390/curroncol30070499.
Pancreatic cancer is rising as one of the leading causes of cancer-related death worldwide. Patients often present with advanced disease, limiting curative treatment options and therefore making management of the disease difficult. Systemic chemotherapy has been an established part of the standard treatment in patients with both locally advanced and metastatic pancreatic cancer. In contrast, the use of radiotherapy has no clear defined role in the treatment of these patients. With the evolving imaging and radiation techniques, radiation could become a plausible intervention. In this review, we give an overview over the available data regarding radiotherapy, chemoradiation, and stereotactic body radiation therapy. We performed a systematic search of Embase and the PubMed database, focusing on studies involving locally advanced pancreatic cancer (or non-resectable pancreatic cancer) and radiotherapy without any limitation for the time of publication. We included randomised controlled trials involving patients with locally advanced pancreatic cancer, including radiotherapy, chemoradiation, or stereotactic body radiation therapy. The included articles represented mainly small patient groups and had a high heterogeneity regarding radiation delivery and modality. This review presents conflicting results concerning the addition of radiation and modality in the treatment regimen. Further research is needed to improve outcomes and define the role of radiation therapy in pancreatic cancer.
胰腺癌是全球导致癌症相关死亡的主要原因之一。患者通常表现为晚期疾病，限制了根治性治疗选择，因此使疾病的治疗变得困难。全身化疗一直是局部晚期和转移性胰腺癌患者标准治疗的重要组成部分。相比之下，放射治疗在这些患者的治疗中没有明确的作用。随着影像学和放射技术的不断发展，放射治疗可能成为一种可行的干预手段。在这篇综述中，我们概述了关于放射治疗、放化疗和立体定向体部放射治疗的现有数据。我们在 Embase 和 PubMed 数据库中进行了系统搜索，重点是涉及局部晚期胰腺癌（或不可切除的胰腺癌）和无时间限制的放射治疗的研究。我们纳入了涉及局部晚期胰腺癌患者的随机对照试验，包括放射治疗、放化疗或立体定向体部放射治疗。纳入的文章主要是小患者组，在放射治疗的提供和方式方面存在很大的异质性。本综述对于添加放射治疗和治疗方案中的治疗方式呈现出相互矛盾的结果。需要进一步的研究来改善结果并确定放射治疗在胰腺癌中的作用。
