Tomic Josip, Wiederstein-Grasser Iris, Schanbacher Monika, Weinberg Annelie Martina
Department of Oral and Maxillofacial Surgery, Medical University of Graz, 8036 Graz, Austria.
Core Facility Experimental Biomodels, Division of Biomedical Research, Medical University of Graz, 8036 Graz, Austria.
J Funct Biomater. 2023 Jun 27;14(7):339. doi: 10.3390/jfb14070339.
orbital floor fractures have not been reconstructed using magnesium biomaterials.
To test technical feasibility, ex vivo caprine and ovine heads (n = 5) were used. Head tissues were harvested from pubescent animals (n = 5; mean age: 3.2 years; mean mass: 26.3 kg) and stored below 11 degrees for 7-10 days. All procedures were performed in a university animal resource facility. Two experienced maxillofacial surgeons performed orbital floor procedures in both orbits of all animals in a step-by-step preplanned dissection. A transconjunctival approach was chosen to repair the orbital floor with three different implants (i.e., magnesium implants; titanium mesh; and polydioxanone or PDO sheets). The position of each implant was evaluated by Cone-beam computed tomography (CBCT).
Axial, coronal, and sagittal plane images showed good positioning of the magnesium plates. The magnesium plates had a radiographic visibility similar to that of the PDO sheets but lower than that of the titanium mesh.
The prototype design study showed a novel indication for magnesium biomaterials. Further testing of this new biomaterial may lead to the first resorbable biomaterial with good mechanical properties for extensive orbital wall defects.
尚未使用镁生物材料对眶底骨折进行重建。
为测试技术可行性，使用了离体的山羊和绵羊头部（n = 5）。头部组织取自青春期动物（n = 5；平均年龄：3.2岁；平均体重：26.3千克），并在11摄氏度以下保存7 - 10天。所有操作均在大学动物资源设施中进行。两名经验丰富的颌面外科医生按照预先计划的分步解剖方法，对所有动物的双侧眼眶进行眶底手术。采用经结膜入路，使用三种不同的植入物（即镁植入物、钛网以及聚二氧六环酮或聚对二氧环己酮片）修复眶底。通过锥形束计算机断层扫描（CBCT）评估每个植入物的位置。
轴向、冠状面和矢状面图像显示镁板位置良好。镁板的射线显影性与聚对二氧环己酮片相似，但低于钛网。
原型设计研究显示了镁生物材料的一种新用途。对这种新型生物材料的进一步测试可能会产生第一种具有良好机械性能、可用于大面积眶壁缺损的可吸收生物材料。
