Allmicroalgae Natural Products S.A., R&D Department, Rua 25 de Abril s/n, 2445-413 Pataias, Portugal.
Microalgae Section, Norwegian Institute for Water Research (NIVA), Økernveien 94, 0579 Oslo, Norway.
Mar Drugs. 2023 Jul 19;21(7):411. doi: 10.3390/md21070411.
Microalgae attract interest worldwide due to their potential for several applications. is one of the first in vitro cultured algae due to their rapid growth and handling easiness. Within this genus, cells exhibit a highly resistant wall and propagate both auto- and heterotrophically. The main goal of the present work is to find scalable ways to produce a highly concentrated biomass of in heterotrophic conditions. growth was improved at the lab-scale by 3.2-fold (from 4.1 to 13 g/L of dry weight) through medium optimization by response surface methodology. Afterwards, scale-up was evaluated in 7 L stirred-tank reactor under fed-batch operation. Then, the optimized medium resulted in an overall productivity of 8.63 g/L/day and a maximum biomass concentration of 69.5 g/L. protein content achieved approximately 31% of dry weight, similar to the protein content of in heterotrophy.
由于其在多个应用领域的潜力，微藻引起了全球的关注。 是最早在体外培养的藻类之一，因为它们生长迅速，易于处理。在这个属中，细胞表现出高度的抗性壁，并以自养和异养的方式繁殖。本工作的主要目标是寻找可规模化的方法，在异养条件下生产高浓度的生物质。通过响应面法对培养基进行优化，在实验室规模上使 的生长提高了 3.2 倍（从 4.1 到 13 g/L 的干重）。之后，在 7 L 搅拌釜式反应器中进行了放大评估，采用分批进料操作。然后，优化后的培养基使总生产力达到 8.63 g/L/天，最大生物量浓度达到 69.5 g/L。 的蛋白质含量达到干重的约 31%，与异养条件下的蛋白质含量相似。
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