Bjørnø L
Ultrasonics. 1986 Sep;24(5):254-9. doi: 10.1016/0041-624x(86)90102-2.
This review presents the state-of-the-art in applications of the second order acoustic non-linearity parameter, B/A, for the characterization of biological media. The close relationship between B/A and the molecular structure of certain liquids, as well as the influence of the inhomogeneous nature of biological materials on B/A, are discussed. The finite amplitude and the thermodynamic methods are presented, and their advantages, disadvantages and accuracy of data produced are discussed. A new and promising procedure, real time non-linear parameter tomography, is critically evaluated and its prospective application for in vivo studies is treated in some depth. B/A values covering a broad variety of biological materials are presented and a world-wide collaborative research scheme is suggested for systematic and in-depth studies of non-linearity of biological media and for clinical exploitations of the results of these studies.
本综述介绍了二阶声学非线性参数B/A在生物介质表征应用方面的最新进展。讨论了B/A与某些液体分子结构之间的密切关系，以及生物材料的非均匀性质对B/A的影响。介绍了有限振幅法和热力学方法，并讨论了它们的优缺点以及所产生数据的准确性。对一种新的、有前景的方法——实时非线性参数断层扫描进行了批判性评估，并深入探讨了其在体内研究中的潜在应用。给出了涵盖多种生物材料的B/A值，并提出了一个全球合作研究计划，用于对生物介质的非线性进行系统深入研究以及对这些研究结果进行临床应用。
