SNORA42 在肿瘤发生中的作用是什么？系统综述。
What is the Role of SNORA42 in Carcinogenesis? A Systematic Review.
机构信息
State University of Maranhão, Campus Zé Doca, Zé Doca, Brazil.
State University of Maranhão, Campus Bacabal, Bacabal, Brazil.
出版信息
Asian Pac J Cancer Prev. 2023 Jul 1;24(7):2217-2223. doi: 10.31557/APJCP.2023.24.7.2217.
OBJECTIVE
Perform a systematic literature review on SNORA42 in carcinogenesis in order to elucidate its importance, its potential use as a biomarker and as a therapeutic target.
METHODS
Using PubMed, SciELO and Science Direct databases as search means, articles that are in line with the scope of the study, written in English, that were published between 2012 and 2022, were selected using the following keywords: "small nucleolar RNA 42", "snoRNA 42" and "SNORA42", as well as searches for the synonyms of this snoRNA (SNORA80E, box H/ACA 42 and ACA42).
RESULT
From a total of 131 studies, seven were selected, in which it was possible to identify that SNORA42 interferes in several biological processes, such as proliferation, migration, invasion, metastasis, apoptosis, and signaling pathways. Among the signaling pathways, the p53 and NF-KappaB pathways stand out. Moreover, it is a potential biomarker for diagnosis, prognosis, and treatment of cancer.
CONCLUSION
The summary of the main information about SNORA42 in the process of carcinogenesis and cancer progression shows that the use of this snoRNA is ideal for future applications in the field of oncology, in which it can be used as a biomarker and therapeutic target. Thus, it is of fundamental importance to carry out new studies to consolidate the applicability of this molecule.
目的
对 SNORA42 在致癌作用中的研究进行系统的文献回顾，以阐明其重要性、作为生物标志物和治疗靶点的潜在用途。
方法
使用 PubMed、SciELO 和 Science Direct 数据库作为搜索手段，选择符合研究范围、发表于 2012 年至 2022 年、用英文撰写的文章，并使用以下关键字进行搜索：“small nucleolar RNA 42”、“snoRNA 42”和“SNORA42”，以及对该 snoRNA 的同义词（SNORA80E、box H/ACA 42 和 ACA42）进行搜索。
结果
从总共 131 项研究中，选择了 7 项研究，这些研究表明 SNORA42 干扰了多种生物学过程，如增殖、迁移、侵袭、转移、凋亡和信号通路。在信号通路中，p53 和 NF-KappaB 通路尤为突出。此外，它还是癌症诊断、预后和治疗的潜在生物标志物。
结论
对 SNORA42 在致癌和癌症进展过程中的主要信息进行总结，表明该 snoRNA 的使用在肿瘤学领域的未来应用中是理想的，它可以用作生物标志物和治疗靶点。因此，开展新的研究来巩固该分子的适用性至关重要。
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