猪繁殖与呼吸综合征病毒NSP11的研究进展

Research Progress on NSP11 of Porcine Reproductive and Respiratory Syndrome Virus.

作者信息

Zheng Yajie, Zhang Hang, Luo Qin, Sha Huiyang, Li Gan, Mu Xuanru, He Yingxin, Kong Weili, Wu Anfeng, Zhang Haoji, Yu Xingang

机构信息

School of Life Science and Engineering, Foshan University, Foshan 528231, China.

Gladstone Institutes of Virology and Immunology, University of California, San Francisco, CA 94158, USA.

出版信息

Vet Sci. 2023 Jul 10;10(7):451. doi: 10.3390/vetsci10070451.

DOI:10.3390/vetsci10070451

PMID:37505856

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10384725/

Abstract

Porcine reproductive and respiratory syndrome (PRRS) is a virulent infectious disease caused by the PRRS virus (PRRSV). The non-structural protein 11 (NSP11) of PRRSV is a nidovirus-specific endonuclease (NendoU), which displays uridine specificity and catalytic functions conserved throughout the entire NendoU family and exerts a wide range of biological effects. This review discusses the genetic evolution of NSP11, its effects on PRRSV replication and virulence, its interaction with other PRRSV and host proteins, its regulation of host immunity, the conserved characteristics of its enzyme activity (NendoU), and its diagnosis, providing an essential theoretical basis for in-depth studies of PRRSV pathogenesis and vaccine design.

摘要

猪繁殖与呼吸综合征（PRRS）是由猪繁殖与呼吸综合征病毒（PRRSV）引起的一种烈性传染病。PRRSV的非结构蛋白11（NSP11）是一种巢式病毒特异性内切核酸酶（NendoU），具有尿苷特异性和在整个NendoU家族中保守的催化功能，并发挥广泛的生物学效应。本文综述了NSP11的遗传进化、其对PRRSV复制和毒力的影响、其与其他PRRSV及宿主蛋白的相互作用、其对宿主免疫的调节、其酶活性（NendoU）的保守特征以及其诊断，为深入研究PRRSV发病机制和疫苗设计提供重要的理论基础。