Messele Yohannes E, Werid Gebremeskel Mamu, Petrovski Kiro
Davies Livestock Research Centre, School of Animal & Veterinary Sciences, University of Adelaide, Roseworthy Campus, Roseworthy, SA 5371, Australia.
Australian Centre for Antimicrobial Resistance Ecology, School of Animal & Veterinary Sciences, University of Adelaide, Roseworthy Campus, Roseworthy, SA 5371, Australia.
Vet Sci. 2023 Jul 21;10(7):479. doi: 10.3390/vetsci10070479.
Antimicrobial resistance (AMR) is an emerging global concern, with the widespread use of antimicrobials in One Health contributing significantly to this phenomenon. Among various antimicrobials, tetracyclines are extensively used in the beef cattle industry, potentially contributing to the development of resistance in bacterial populations. This meta-analysis aimed to examine the association between tetracycline use in beef cattle and the development of tetracycline resistance in isolates. A comprehensive search was conducted using multiple databases to gather relevant observational studies evaluating tetracycline use and tetracycline resistance in isolates from beef cattle. The rate of tetracycline resistance from each study served as the effect measure and was pooled using a random-effects model, considering possible disparities among studies. The meta-analysis of 14 prospective longitudinal studies resulted in a 0.31 prevalence of tetracycline resistance in in non-intervention (no exposure), contrasting numerically elevated resistance rates in the intervention (exposed) groups of 0.53 and 0.39 in those receiving tetracyclines via feed or systemically, respectively. Despite the observed numerical differences, no statistically significant differences existed between intervention and non-intervention groups, challenging the conventional belief that antimicrobial use in livestock inherently leads to increased AMR. The findings of this study underscore the need for additional research to fully understand the complex relationship between antimicrobial use and AMR development. A considerable degree of heterogeneity across studies, potentially driven by variations in study design and diverse presentation of results, indicates the intricate and complex nature of AMR development. Further research with standardized methodologies might help elucidate the relationship between tetracycline use and resistance in isolated from beef cattle.
抗菌药物耐药性（AMR）是一个新出现的全球关注问题，“同一健康”理念下抗菌药物的广泛使用对这一现象起到了显著的推动作用。在各类抗菌药物中，四环素类药物在肉牛养殖业中被广泛使用，这可能促使细菌群体产生耐药性。这项荟萃分析旨在研究肉牛使用四环素与分离菌株中四环素耐药性产生之间的关联。通过多个数据库进行了全面检索，以收集评估肉牛分离菌株中四环素使用情况和四环素耐药性的相关观察性研究。每项研究中的四环素耐药率作为效应量，并使用随机效应模型进行汇总，同时考虑到研究之间可能存在的差异。对14项前瞻性纵向研究的荟萃分析结果显示，在非干预（无暴露）组中，分离菌株的四环素耐药率为0.31，相比之下，通过饲料或全身途径接受四环素的干预（暴露）组的耐药率分别在数值上有所升高，为0.53和0.39。尽管观察到了数值差异，但干预组和非干预组之间不存在统计学上的显著差异，这对传统观念即牲畜使用抗菌药物必然会导致抗菌药物耐药性增加提出了挑战。本研究结果强调需要进行更多研究，以全面了解抗菌药物使用与抗菌药物耐药性产生之间的复杂关系。研究之间存在相当程度的异质性，这可能是由研究设计的差异和结果呈现方式的多样性所驱动的，这表明抗菌药物耐药性产生具有复杂的本质。采用标准化方法进行进一步研究可能有助于阐明肉牛分离菌株中四环素使用与耐药性之间的关系。
