Gastroenterology, Hepatology & Digestive Endoscopy Section, Department of Medicine and Surgery, University of Perugia.
Gastroenterology & Hepatology Unit, Santa Maria della Misericordia Hospital.
Eur J Gastroenterol Hepatol. 2023 Sep 1;35(9):985-988. doi: 10.1097/MEG.0000000000002615. Epub 2023 Jul 17.
Many colorectal diseases depend on complex interactions between several pathophysiological factors, including the intestinal microbiota. In recent years, the widespread use of antibiotics has been recognized as a main cause of intestinal dysbiosis and a favouring factor for Clostridioides difficile infection. The latter, in addition, causes infectious diarrhoea, pseudomembranous colitis, and toxic megacolon by means of its toxins (A and, especially, B), is characterized by frequent relapses; thus, its persistence in a host may be long-lasting. Based on recent experimental evidence, here we analyse the possibility that, similarly to other bacteria, Clostridioides difficile may be considered a potential carcinogen for colorectal cancer.
许多结直肠疾病依赖于几个病理生理因素之间的复杂相互作用，包括肠道微生物群。近年来，抗生素的广泛使用已被认为是肠道菌群失调的主要原因，也是艰难梭菌感染的有利因素。后者通过其毒素（A 和，尤其是，B）引起感染性腹泻、伪膜性结肠炎和中毒性巨结肠，其特征是频繁复发；因此，它在宿主中的持续存在可能是持久的。基于最近的实验证据，在这里我们分析了这样一种可能性，即类似于其他细菌，艰难梭菌也可能被认为是结直肠癌的潜在致癌物质。
