Moore F M, Emerson W E, Cotter S M, DeLellis R A
Vet Pathol. 1986 Jul;23(4):386-91. doi: 10.1177/030098588602300407.
Peripheral lymph node enlargement was found in 14 of a series of 132 feline lymph node biopsy specimens. Six of nine cats tested had antibodies for feline leukemia virus (FeLV). Half of the cats were clinically normal while the remainder had fever, lethargy, anorexia, and hepatosplenomegaly. There was severe distortion of lymph nodal architecture with variable loss of discernible follicles and sinuses. Histiocytes, lymphocytes, immunoblasts, and plasma cells were present in expanded paracortical regions which encroached on, and occasionally effaced, lymphoid follicles. Postcapillary venules were numerous and prominent throughout the paracortex. The lymphadenopathy was most commonly transient (86% of cases) with subsequent development of lymphoma in one cat. Lymph nodes from seven kittens with experimental FeLV infection were compared with spontaneously enlarged lymph nodes; four of seven had B and T lymphocyte hyperplasia with normal nodal architecture. Three had partial loss of nodal architecture as a result of expanded paracortical regions populated largely by histiocytes and lymphocytes. Proliferation of postcapillary venules was not prominent in nodes from FeLV-infected cats. The cause of spontaneous lymph node hyperplasia of young cats was not determined. However, the similarity of lesions to those of kittens with experimental FeLV infection and the association with FeLV by serologic tests in six of nine cats suggest that this retrovirus may be involved in the pathogenesis of the lesion.
在132份猫淋巴结活检标本系列中，有14份发现外周淋巴结肿大。9只接受检测的猫中有6只具有猫白血病病毒（FeLV）抗体。一半的猫临床正常，其余的则有发热、嗜睡、厌食和肝脾肿大。淋巴结结构严重扭曲，可见的滤泡和窦可变地丧失。组织细胞、淋巴细胞、免疫母细胞和浆细胞存在于扩大的副皮质区域，该区域侵犯并偶尔取代淋巴滤泡。毛细血管后微静脉在整个副皮质中大量且突出。淋巴结病最常见为短暂性（86%的病例），1只猫随后发生淋巴瘤。将7只实验性感染FeLV的小猫的淋巴结与自发性肿大的淋巴结进行比较；7只中有4只出现B和T淋巴细胞增生，淋巴结结构正常。3只由于主要由组织细胞和淋巴细胞构成的副皮质区域扩大而出现部分淋巴结结构丧失。FeLV感染猫的淋巴结中毛细血管后微静脉的增殖不明显。未确定幼猫自发性淋巴结增生的原因。然而，病变与实验性感染FeLV的小猫的病变相似，且9只猫中有6只通过血清学检测与FeLV相关，这表明这种逆转录病毒可能参与了病变的发病机制。
