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Not a small frog in a big pond: targeting bradykinin receptor B2 signaling in vascular smooth muscle cells for treatment of hypertension.

作者信息

Higashikuni Yasutomi, Liu Wenhao, Sata Masataka

机构信息

Department of Cardiovascular Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Department of Cardiovascular Medicine, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima-shi, Tokushima, 770-8503, Japan.

出版信息

Hypertens Res. 2023 Oct;46(10):2415-2418. doi: 10.1038/s41440-023-01385-w. Epub 2023 Jul 28.

DOI:10.1038/s41440-023-01385-w
PMID:37507534
Abstract
摘要

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Not a small frog in a big pond: targeting bradykinin receptor B2 signaling in vascular smooth muscle cells for treatment of hypertension.并非大池塘里的小青蛙：靶向血管平滑肌细胞中的缓激肽受体B2信号通路治疗高血压
Hypertens Res. 2023 Oct;46(10):2415-2418. doi: 10.1038/s41440-023-01385-w. Epub 2023 Jul 28.
2
Maximakinin reduced intracellular Ca level in vascular smooth muscle cells through AMPK/ERK1/2 signaling pathways.麦司卡林通过 AMPK/ERK1/2 信号通路降低血管平滑肌细胞内的 Ca 水平。
Hypertens Res. 2023 Aug;46(8):1949-1960. doi: 10.1038/s41440-023-01330-x. Epub 2023 Jun 1.
3
The bradykinin B2 receptor is a delayed early response gene for platelet-derived growth factor in arterial smooth muscle cells.缓激肽B2受体是动脉平滑肌细胞中血小板衍生生长因子的延迟早期反应基因。
J Biol Chem. 1996 Jun 7;271(23):13324-32. doi: 10.1074/jbc.271.23.13324.
4
Bradykinin regulates calpain and proinflammatory signaling through TRPM7-sensitive pathways in vascular smooth muscle cells.缓激肽通过血管平滑肌细胞中TRPM7敏感途径调节钙蛋白酶和促炎信号。
Am J Physiol Regul Integr Comp Physiol. 2009 Feb;296(2):R201-7. doi: 10.1152/ajpregu.90602.2008. Epub 2008 Sep 17.
5
B1 and B2 kinin receptors mediate distinct patterns of intracellular Ca2+ signaling in single cultured vascular smooth muscle cells.B1和B2缓激肽受体在单个培养的血管平滑肌细胞中介导不同模式的细胞内钙离子信号传导。
Mol Pharmacol. 1996 Jul;50(1):128-39.
6
Angiotensin-converting enzyme inhibitor ramiprilat interferes with the sequestration of the B2 kinin receptor within the plasma membrane of native endothelial cells.血管紧张素转换酶抑制剂雷米普利拉干扰天然内皮细胞质膜内B2激肽受体的隔离。
Circulation. 1999 Apr 20;99(15):2034-40. doi: 10.1161/01.cir.99.15.2034.
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Receptors for kinins: from classical pharmacology to molecular biology.
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Bradykinin receptors and receptor ligands (with special emphasis on vascular receptors).缓激肽受体与受体配体（特别强调血管受体）。
Regul Pept. 1996 Aug 27;65(1):83-9. doi: 10.1016/0167-0115(96)00076-6.
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Bradykinin activates the Janus-activated kinase/signal transducers and activators of transcription (JAK/STAT) pathway in vascular endothelial cells: localization of JAK/STAT signalling proteins in plasmalemmal caveolae.缓激肽激活血管内皮细胞中的Janus激活激酶/信号转导子和转录激活子（JAK/STAT）通路：JAK/STAT信号蛋白在质膜小窝中的定位。
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Interaction between growth factors and kinins in arterial smooth muscle cells.生长因子与激肽在动脉平滑肌细胞中的相互作用。
Immunopharmacology. 1996 Jun;33(1-3):16-23. doi: 10.1016/0162-3109(96)00076-8.

本文引用的文献

1
Function and structure of bradykinin receptor 2 for drug discovery.缓激肽受体 2 的功能和结构及其在药物研发中的应用。
Acta Pharmacol Sin. 2023 Mar;44(3):489-498. doi: 10.1038/s41401-022-00982-8. Epub 2022 Sep 8.
2
The antihypertensive effect of MK on spontaneously hypertensive rats through the AMPK/Akt/eNOS/NO and ERK1/2/Cx43 signaling pathways.MK通过AMPK/Akt/eNOS/NO和ERK1/2/Cx43信号通路对自发性高血压大鼠的降压作用。
Hypertens Res. 2021 Jul;44(7):781-790. doi: 10.1038/s41440-021-00638-w. Epub 2021 Mar 11.
3
Involvement of sarco/endoplasmic reticulum Ca-ATPase (SERCA) in mPRα (PAQR7)-mediated progesterone induction of vascular smooth muscle relaxation.
肌浆网/内质网钙-ATP酶（SERCA）参与膜孕激素受体α（mPRα，PAQR7）介导的孕酮诱导的血管平滑肌舒张。
Am J Physiol Endocrinol Metab. 2021 Mar 1;320(3):E453-E466. doi: 10.1152/ajpendo.00359.2020. Epub 2021 Jan 11.
4
Outcomes Associated With Use of a Kinin B2 Receptor Antagonist Among Patients With COVID-19.COVID-19 患者使用激肽 B2 受体拮抗剂的相关结局。
JAMA Netw Open. 2020 Aug 3;3(8):e2017708. doi: 10.1001/jamanetworkopen.2020.17708.
5
VPO1 Modulates Vascular Smooth Muscle Cell Phenotypic Switch by Activating Extracellular Signal-regulated Kinase 1/2 (ERK 1/2) in Abdominal Aortic Aneurysms.VPO1 通过激活腹主动脉瘤中的细胞外信号调节激酶 1/2（ERK1/2）来调节血管平滑肌细胞表型转换。
J Am Heart Assoc. 2018 Sep 4;7(17):e010069. doi: 10.1161/JAHA.118.010069.
6
Bradykinin B2 and dopamine D2 receptors form a functional dimer.缓激肽 B2 受体和多巴胺 D2 受体形成功能性二聚体。
Biochim Biophys Acta Mol Cell Res. 2017 Oct;1864(10):1855-1866. doi: 10.1016/j.bbamcr.2017.07.012. Epub 2017 Jul 27.
7
Treatment Effect and Safety of Icatibant in Pediatric Patients with Hereditary Angioedema.依替巴肽治疗儿童遗传性血管性水肿的疗效和安全性。
J Allergy Clin Immunol Pract. 2017 Nov-Dec;5(6):1671-1678.e2. doi: 10.1016/j.jaip.2017.04.010. Epub 2017 Jun 7.
8
Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders.血管平滑肌收缩机制及平滑肌疾病的药物治疗基础
Pharmacol Rev. 2016 Apr;68(2):476-532. doi: 10.1124/pr.115.010652.
9
AMPK Dilates Resistance Arteries via Activation of SERCA and BKCa Channels in Smooth Muscle.AMPK通过激活平滑肌中的肌浆网钙ATP酶（SERCA）和大电导钙激活钾通道（BKCa通道）使阻力动脉扩张。
Hypertension. 2015 Jul;66(1):108-16. doi: 10.1161/HYPERTENSIONAHA.115.05514. Epub 2015 Jun 1.
10
AMPK--sensing energy while talking to other signaling pathways.AMPK——感知能量的同时与其他信号通路进行交流。
Cell Metab. 2014 Dec 2;20(6):939-52. doi: 10.1016/j.cmet.2014.09.013. Epub 2014 Oct 30.