Universidad de Buenos Aires, Facultad de Odontología, Cátedra de Biofísica y Bioestadística, Buenos Aires, Argentina.
Universidad de Buenos Aires, Facultad de Odontología, Cátedra de Medicina Interna, Buenos Aires, Argentina.
Clin Rheumatol. 2024 Jan;43(1):95-102. doi: 10.1007/s10067-023-06718-1. Epub 2023 Jul 28.
To investigate the association among rheumatoid arthritis (RA), saliva production, and periodontal status.
An observational study was carried out on 103 subjects with RA and 103 without RA matched by sex and age. Rheumatologic evaluation included serological and clinical variables. A full mouth periodontal examination was performed according to the American Academy of Periodontology (1999). Resting and stimulated whole salivary flows were determined after spiting during 5 min.
RA was associated with a higher prevalence of severe periodontitis (12% vs. 4%), with a marked reduction in resting and stimulated saliva production, and with a higher prevalence of resting (19% vs. 0%) and also stimulated hyposalivation (54% vs. 10%), compared with the control group. The differences in mean resting and stimulated salivary flows between RA and control groups persisted after the exclusion of people with hyposalivation. Saliva production was not associated with the presence or the severity of periodontal disease, or with the rheumatic clinical characteristics of the patients.
More than 50% of people with RA have some degree of reduction in their salivary flows, an affection not associated with the periodontal status or rheumatic activity, which are the expression of the two related inflammatory diseases. The influence of autonomic dysfunction on hyposalivation can be considered. While periodontitis would be a disease-associated comorbidity of RA, poor saliva production should be included among the extra-articular manifestations. Key Points • Rheumatoid arthritis patients are more prone to suffer from periodontitis and/or hyposalivation. • Periodontal disease is more prevalent in people with rheumatoid arthritis and also an association was found between the severities of both pathologies. • More than 50% of people with RA would have some degree of reduction in their salivary flows, an affection not associated with the periodontal status or rheumatic activity. • Reduced saliva production in rheumatoid arthritis patients should be included among the extra-articular manifestations.
探讨类风湿关节炎（RA）、唾液分泌和牙周状况之间的关系。
对 103 例 RA 患者和 103 例性别和年龄匹配的无 RA 患者进行了一项观察性研究。风湿学评估包括血清学和临床变量。根据美国牙周病学会（1999 年）进行全口牙周检查。在 5 分钟内吐口水后，测定静止和刺激全唾液流量。
RA 患者牙周炎严重程度（12%比 4%）、静止和刺激唾液分泌量明显减少、静止性（19%比 0%）和刺激性低流（54%比 10%）的发生率明显升高，与对照组相比。RA 组与对照组之间的平均静止和刺激唾液流量差异在排除低流人群后仍然存在。唾液分泌量与牙周病的存在或严重程度或患者的风湿临床特征无关。
超过 50%的 RA 患者有某种程度的唾液流量减少，这种影响与牙周状况或风湿活动无关，这是两种相关炎症性疾病的表现。自主神经功能障碍对低流的影响可以考虑。虽然牙周炎是 RA 的一种疾病相关合并症，但低流应包括在关节外表现中。
类风湿关节炎患者更易患牙周炎和/或唾液分泌减少。
牙周病在类风湿关节炎患者中更为常见，且两种疾病的严重程度之间存在关联。
超过 50%的 RA 患者的唾液流量会有一定程度的减少，这种情况与牙周状况或风湿活动无关。
类风湿关节炎患者的唾液分泌减少应包括在关节外表现中。
