Department of Paediatric Orthopaedic Surgery, Amiens University Hospital, Jules Verne University of Picardie, F-80054 Amiens, France.
MP3CV-EA7517, CURS-Amiens University Medical Center, Jules Verne University of Picardie, F-80025 Amiens, France.
Cells. 2023 Jul 24;12(14):1918. doi: 10.3390/cells12141918.
The induced membrane technique is an innovative approach for repairing critical bone defects and has been applied recently in patients with congenital pseudarthrosis of the tibia (CPT). CPT is frequently associated with neurofibromatosis type 1 (NF1). Here, we briefly describe the clinical results of the induced membrane technique in NF1-deficient patients with CPT and in an animal model of CPT. Furthermore, we discuss the hypotheses used to explain inconsistent outcomes for the induced membrane technique in CPT-especially when associated with NF1.
诱导膜技术是修复临界骨缺损的一种创新方法，最近已应用于先天性胫骨假关节（CPT）患者。CPT 常与神经纤维瘤病 1 型（NF1）相关。在这里，我们简要描述了诱导膜技术在 NF1 缺陷型 CPT 患者和 CPT 动物模型中的临床结果。此外，我们还讨论了用于解释诱导膜技术在 CPT 中不一致结果的假设，尤其是当 CPT 与 NF1 相关时。
