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一项由家长主导的记忆重构干预措施的随机对照试验,旨在减轻幼儿疫苗注射相关的痛苦和疼痛。

A Randomized Controlled Trial of a Parent-Led Memory-Reframing Intervention to Reduce Distress and Pain Associated with Vaccine Injections in Young Children.

作者信息

Pavlova Maria, Pirwani Atiqa F, Thomas Jody, Birnie Kathryn A, Wan Michelle, Chambers Christine T, Noel Melanie

机构信息

Department of Psychology, University of Calgary, Calgary, AB T2N 1N4, Canada.

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.

出版信息

Children (Basel). 2023 Jun 22;10(7):1099. doi: 10.3390/children10071099.

DOI:10.3390/children10071099
PMID:37508596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10378095/
Abstract

Children remember their memories of pain long after the painful experience is over. Those memories predict higher levels of future pain intensity. Young children's memories can be reframed to be less distressing. Parents and the way they reminisce about past events with their children play a key role in the formation of pain memories. A novel parent-led memory-reframing intervention changed children's memories of post-surgical pain to be less distressing. The intervention efficacy in the context of vaccine injections is unclear. This registered randomized controlled trial (NCT05217563) aimed to fill this gap. Seventy-four children aged 4.49 years ( = 1.05) and scheduled to obtain two COVID-19 vaccine injections and one of their parents were randomized to receive: (1) standard care; (2) standard care and memory-reframing information; and (3) standard care and memory-reframing information with verbal instructions. Children reported their pain after vaccine injections. One week after the first vaccination, children reported memory of pain. Parents reported their use of memory-reframing strategies and intervention feasibility and acceptability. The intervention did not result in significant differences in children's recalled or future pain. Parents rated the intervention as acceptable and feasible.

摘要

在痛苦经历结束很久之后,孩子们仍会记得他们对疼痛的记忆。这些记忆预示着未来更高水平的疼痛强度。幼儿的记忆可以被重新构建,从而不那么令人痛苦。父母以及他们与孩子回忆过去事件的方式在疼痛记忆的形成中起着关键作用。一种由父母主导的新型记忆重构干预措施改变了孩子们对手术后疼痛的记忆,使其不那么令人痛苦。在疫苗注射的背景下,这种干预措施的效果尚不清楚。这项注册随机对照试验(NCT05217563)旨在填补这一空白。74名年龄为4.49岁(标准差 = 1.05)且计划接种两剂新冠疫苗的儿童及其一名家长被随机分配接受:(1)标准护理;(2)标准护理和记忆重构信息;(3)标准护理和带有口头指导的记忆重构信息。孩子们在接种疫苗后报告了他们的疼痛情况。在第一次接种疫苗一周后,孩子们报告了对疼痛的记忆。家长们报告了他们使用记忆重构策略的情况以及干预措施的可行性和可接受性。该干预措施在孩子们回忆的疼痛或未来疼痛方面并未产生显著差异。家长们认为该干预措施是可接受且可行的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67e6/10378095/a1736ec4b0ae/children-10-01099-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67e6/10378095/ff229ed2dfe2/children-10-01099-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67e6/10378095/a1736ec4b0ae/children-10-01099-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67e6/10378095/ff229ed2dfe2/children-10-01099-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67e6/10378095/a1736ec4b0ae/children-10-01099-g002.jpg

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Rapid local anesthesia in children enhanced by STAR particles: a first-in-humans, randomized clinical trial.STAR颗粒增强儿童快速局部麻醉:一项首次人体随机临床试验
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