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雌性大鼠膈下迷走神经的组织及其与腹腔神经丛和卵巢的连接

Organization of the Subdiaphragmatic Vagus Nerve and Its Connection with the Celiac Plexus and the Ovaries in the Female Rat.

作者信息

Rivera-Castro María E, Pastelín César F, Bravo-Benítez Juan, Morán Carolina

机构信息

Doctorado en Investigaciones Cerebrales, Instituto de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa, Veracruz 91190, Mexico.

Centro de Investigación en Fisicoquímica de Materiales, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, Puebla, Puebla 72960, Mexico.

出版信息

Brain Sci. 2023 Jul 6;13(7):1032. doi: 10.3390/brainsci13071032.

DOI:10.3390/brainsci13071032
PMID:37508964
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10377505/
Abstract

Communication between the ovaries and the central nervous system occurs by peripheral innervation through the celiac plexus, superior ovarian nerve, and ovarian plexus nerve. The vagus nerve is involved in regulating the ovaries, but the neuroanatomical pathway that links them is not clear. Adult female rats were used for gross anatomy, acetylcholinesterase histochemistry, and the immunofluorescence analysis of tyrosine hydroxylase (TH), choline acetyltransferase (ChAT), and tryptophan hydroxylase 2 (TPH). The results obtained indicate that the right vagus nerve (RVN) travels parallel and caudal to the esophagus, where three nerve branches were identified. Also, a right vagal plexus (RVP) formed by microganglia was described, establishing communication with the celiac plexus, and was mainly reactive to tyrosine hydroxylase (TH); some serotoninergic and cholinergic neurons were also found. The left vagus nerve (LVN) travels over the esophagus, bifurcates before its insertion into the stomach and enters the RCG. This neuroanatomical and biochemical description of the RVN and LVN in the rat suggests the RVP is formed by presynaptic catecholaminergic terminals and cholinergic neurons. This information could support detailed studies of communication between the vagus nerve and the ovaries and identify the type of neural signaling involved in abdominal control of the vagus nerve.

摘要

卵巢与中枢神经系统之间的通讯是通过腹腔丛、卵巢上神经和卵巢丛神经的外周神经支配来实现的。迷走神经参与调节卵巢，但连接它们的神经解剖学通路尚不清楚。成年雌性大鼠用于大体解剖、乙酰胆碱酯酶组织化学以及酪氨酸羟化酶（TH）、胆碱乙酰转移酶（ChAT）和色氨酸羟化酶2（TPH）的免疫荧光分析。所得结果表明，右迷走神经（RVN）与食管平行并位于其尾侧，在此处可识别出三个神经分支。此外，还描述了由微神经节形成的右迷走神经丛（RVP），它与腹腔丛建立了联系，并且主要对酪氨酸羟化酶（TH）有反应；还发现了一些5-羟色胺能和胆碱能神经元。左迷走神经（LVN）在食管上方走行，在插入胃之前分支并进入胃网膜右动脉。对大鼠RVN和LVN的这种神经解剖学和生物化学描述表明，RVP是由突触前儿茶酚胺能终末和胆碱能神经元形成的。这些信息可为迷走神经与卵巢之间通讯的详细研究提供支持，并确定参与迷走神经腹部控制的神经信号类型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/495f/10377505/41755004931c/brainsci-13-01032-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/495f/10377505/4fb17a82ec64/brainsci-13-01032-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/495f/10377505/ed28f6401cc5/brainsci-13-01032-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/495f/10377505/ed3026ebf4ce/brainsci-13-01032-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/495f/10377505/41755004931c/brainsci-13-01032-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/495f/10377505/4fb17a82ec64/brainsci-13-01032-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/495f/10377505/ed28f6401cc5/brainsci-13-01032-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/495f/10377505/ed3026ebf4ce/brainsci-13-01032-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/495f/10377505/41755004931c/brainsci-13-01032-g004.jpg

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Suprachiasmatic nucleus and vagus nerve trigger preovulatory LH and ovulation.视交叉上核和迷走神经触发排卵前促黄体生成素分泌及排卵。
Reproduction. 2023 Jan 6;165(2):147-157. doi: 10.1530/REP-22-0119. Print 2023 Feb 1.
3
Structure and Functions of the Vagus Nerve in Mammals.哺乳动物迷走神经的结构和功能。
自主神经系统在多囊卵巢综合征中的作用。
Front Endocrinol (Lausanne). 2024 Jan 19;14:1295061. doi: 10.3389/fendo.2023.1295061. eCollection 2023.
Compr Physiol. 2022 Aug 11;12(4):3989-4037. doi: 10.1002/cphy.c210042.
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Intrinsic innervation of the ovary and its variations in the rat senescence process.卵巢的内在神经支配及其在大鼠衰老过程中的变化。
J Mol Histol. 2022 Apr;53(2):347-356. doi: 10.1007/s10735-022-10069-7. Epub 2022 Feb 25.
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Divergence of neuroimmune circuits activated by afferent and efferent vagal nerve stimulation in the regulation of inflammation.传入和传出迷走神经刺激调节炎症中激活的神经免疫回路的分歧。
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