Budhiraja Shreya, Najem Hinda, Tripathi Shashwat, Wadhawani Nitin R, Horbinski Craig, McCord Matthew, Lenzen Alicia C, Heimberger Amy B, DeCuypere Michael
Division of Pediatric Neurosurgery, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA.
Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Cancers (Basel). 2023 Jul 18;15(14):3655. doi: 10.3390/cancers15143655.
Utilizing a Scoping Review strategy in the domain of immune biology to identify immune therapeutic targets, knowledge gaps for implementing immune therapeutic strategies for pediatric brain tumors was assessed. The analysis demonstrated limited efforts to date to characterize and understand the immunological aspects of tumor biology with an over-reliance on observations from the adult glioma population. Foundational knowledge regarding the frequency and ubiquity of immune therapeutic targets is an area of unmet need along with the development of immune-competent pediatric tumor models to test therapeutics and especially combinatorial treatment. Opportunities arise in the evolution of pediatric tumor classification from histological to molecular with targeted immune therapeutics.
利用免疫生物学领域的范围综述策略来识别免疫治疗靶点，评估了实施小儿脑肿瘤免疫治疗策略的知识差距。分析表明，迄今为止，在表征和理解肿瘤生物学的免疫学方面所做的努力有限，过度依赖于来自成人胶质瘤人群的观察结果。关于免疫治疗靶点的频率和普遍性的基础知识是一个未满足的需求领域，同时还需要开发具有免疫活性的小儿肿瘤模型来测试治疗方法，尤其是联合治疗。随着小儿肿瘤分类从组织学向分子学发展以及靶向免疫治疗的出现，机遇也随之而来。
