Mokhtar Nazarine, Doly Stephane, Courteix Christine
NEURO-DOL, INSERM (Institut National de la Santé et de la Recherche Médicale), Université Clermont Auvergne, 63000 Clermont-Ferrand, France.
Biomedicines. 2023 Jul 6;11(7):1924. doi: 10.3390/biomedicines11071924.
The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) is involved in numerous physiological functions and plays a key role in pain modulation including neuropathic pain. Diabetic neuropathy is a common complication of diabetes mellitus often accompanied by chronic neuropathic pain. Animal models of diabetes offer relevant tools for studying the pathophysiological mechanisms and pharmacological sensitivity of diabetic neuropathic pain and for identifying new therapeutic targets. In this review, we report data from preclinical work published over the last 15 years on the analgesic activity of drugs acting on the serotonergic system, such as serotonin and noradrenaline reuptake inhibitor (SNRI) antidepressants, and on the involvement of certain serotonin receptors-in particular 5-HT, 5-HT and 5-HT receptors-in rodent models of painful diabetic neuropathy.
神经递质5-羟色胺（5-羟色胺，5-HT）参与多种生理功能，在包括神经性疼痛在内的疼痛调节中起关键作用。糖尿病性神经病变是糖尿病的常见并发症，常伴有慢性神经性疼痛。糖尿病动物模型为研究糖尿病性神经病变性疼痛的病理生理机制和药理敏感性以及确定新的治疗靶点提供了相关工具。在本综述中，我们报告了过去15年发表的临床前研究数据，这些数据涉及作用于5-羟色胺能系统的药物（如5-羟色胺和去甲肾上腺素再摄取抑制剂（SNRI）类抗抑郁药）的镇痛活性，以及某些5-羟色胺受体（特别是5-HT、5-HT和5-HT受体）在糖尿病性神经病变性疼痛啮齿动物模型中的作用。
