Xu Dan, Huang Minmin, Lei Jiao, Song Hongxin, Hu Liangbin, Mo Haizhen
School of Food Science and Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.
Foods. 2023 Jul 8;12(14):2644. doi: 10.3390/foods12142644.
Aflatoxin B1 (AFB1), as a class I carcinogen, poses a substantial health risk to individuals. Contamination of food sources, particularly grains and nuts, with () contributes to the prevalence of AFB1. The impact of global warming has spurred research into the development of AFB1 prevention technologies. While edible fungi have shown potential in detoxifying AFB1, there is a scarcity of literature on the application of () in this context. This study aimed to investigate the ability and underlying mechanism of mycelia to adsorb aflatoxin B1, as well as evaluate its protective effects on the AFB1-induced liver damage in SD rats. Additionally, the effects of temperature, time, pH, and reaction ratio on the adsorption rate were examined. Combining thermodynamic and kinetic data, the adsorption process was characterized as a complex mechanism primarily driven by chemical adsorption. In SD rats, the mycelia exhibited alleviation of AFB1-induced liver damage. The protective effects on the liver attributed to mycelia may involve a reduction in AFB1 adsorption in the intestine, mitigation of oxidative stress, and augmentation of second-phase detoxification enzyme activity. The adsorption method for AFB1 not only ensures safety and non-toxicity, but also represents a dietary regulation strategy for achieving effective defense against AFB1.
黄曲霉毒素B1（AFB1）作为一类致癌物，对个体健康构成重大风险。食物来源，特别是谷物和坚果受到（此处原文括号内容缺失）污染，导致AFB1普遍存在。全球变暖的影响促使人们对AFB1预防技术的开发进行研究。虽然食用菌已显示出对AFB1解毒的潜力，但关于（此处原文括号内容缺失）在这方面应用的文献却很匮乏。本研究旨在探讨（此处原文缺失具体名称）菌丝体吸附黄曲霉毒素B1的能力及潜在机制，并评估其对AFB1诱导的SD大鼠肝损伤的保护作用。此外，还研究了温度、时间、pH值和反应比例对吸附率的影响。结合热力学和动力学数据，吸附过程的特征是一种主要由化学吸附驱动的复杂机制。在SD大鼠中，（此处原文缺失具体名称）菌丝体减轻了AFB1诱导的肝损伤。（此处原文缺失具体名称）菌丝体对肝脏的保护作用可能包括减少肠道对AFB1的吸附、减轻氧化应激以及增强二期解毒酶活性。AFB1的吸附方法不仅确保了安全性和无毒性，而且代表了一种实现对AFB1有效防御的饮食调节策略。
