Yildiz Halil, Lepere Charlotte, Zorzi Giulia, Gheysens Olivier, Roodhans Fabien, Pothen Lucie
Department of Internal Medicine and Infectious Diseases, Cliniques Universitaires Saint-Luc, Institute of Clinical and Experimental Research (IREC), Université Catholique de Louvain (UCLouvain), Avenue Hippocrate 10, B-1200 Brussels, Belgium.
Department of Internal Medicine, Hôpital d'Arlon (Vivalia), 6700 Arlon, Belgium.
Diagnostics (Basel). 2023 Jul 8;13(14):2316. doi: 10.3390/diagnostics13142316.
[F]FDG-PET/CT is a useful tool for diagnosis and cancer detection in idiopathic inflammatory myopathies (IIMs), especially polymyositis (PM) and dermatomyositis (DM). Data deriving from Europe are lacking. We describe [F]FDG-PET/CT results in a Belgian cohort with IIMs, focusing on patients with PM and DM. All of the cases of IIMs admitted between December 2010 and January 2023 to the Cliniques Universitaires Saint-Luc (Belgium) were retrospectively reviewed. In total, 44 patients were identified with suspected IIMs; among them, 29 were retained for final analysis. The mean age of the retained patients was 48.7 years; 19 patients were female (65.5%). Twenty-two patients had DM and seven had PM. The mean serum creatinine kinase (CK) and the mean CRP levels were 3125 UI/L and 30.3 mg/L, respectively. [F]FDG-PET/CT imaging was performed for 27 patients, detecting interstitial lung diseases (ILDs) in 7 patients (25.9%), cancer in 3 patients (11.1%), and abnormal muscle FDG uptake compatible with myositis in 13 patients (48.1%). All of the patients who were detected to have ILDs via PET/CT imaging were confirmed using a low-dose lung CT scan. Among the patients who were detected to have abnormal muscle FDG uptake via PET/CT scans (13/28), the EMG was positive in 12 patients ( = 0.004), while the MRI was positive in 8 patients ( = 0.02). We further observed that there was a significantly higher level of CK in the group with abnormal muscle FDG uptake ( = 0.008). Our study showed that PET/CT is useful for detecting cancer and ILDs. We showed that the detection of abnormal muscle uptake via PET/CT was in accordance with EMG and MRI results, as well as with the mean CK value, and that the presence of dyspnea was significantly associated with the presence of ILDs detected via PET/CT imaging ( = 0.002).
[F]氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（FDG-PET/CT）是诊断和检测特发性炎性肌病（IIM），尤其是多发性肌炎（PM）和皮肌炎（DM）中癌症的有用工具。来自欧洲的数据尚缺。我们描述了比利时一组IIM患者的FDG-PET/CT结果，重点关注PM和DM患者。对2010年12月至2023年1月间收治于比利时圣吕克大学医院的所有IIM病例进行回顾性分析。共识别出44例疑似IIM患者；其中，29例被纳入最终分析。纳入患者的平均年龄为48.7岁；19例为女性（65.5%）。22例患者患有DM，7例患有PM。血清肌酸激酶（CK）平均水平和CRP平均水平分别为3125 UI/L和30.3 mg/L。对27例患者进行了FDG-PET/CT成像，7例患者（25.9%）检测到间质性肺疾病（ILD），3例患者（11.1%）检测到癌症，13例患者（48.1%）检测到与肌炎相符的肌肉FDG摄取异常。所有通过PET/CT成像检测到有ILD的患者均通过低剂量肺部CT扫描得以确诊。在通过PET/CT扫描检测到肌肉FDG摄取异常的患者中（13/28），12例患者肌电图呈阳性（P = 0.004），而8例患者磁共振成像呈阳性（P = 0.02）。我们进一步观察到，肌肉FDG摄取异常组的CK水平显著更高（P = 0.008）。我们的研究表明，PET/CT有助于检测癌症和ILD。我们发现，通过PET/CT检测到的肌肉摄取异常与肌电图和磁共振成像结果以及CK平均值相符，并且呼吸困难的存在与通过PET/CT成像检测到的ILD的存在显著相关（P = 0.002）。
