Giarda Federico, Agostini Adele, Colonna Stefano, Sciumè Luciana, Meroni Alberto, Beretta Giovanna, Dalla Costa Davide
Unit of Rehabilitation Medicine and Neurorehabilitation, Department of Neuroscience, ASST Niguarda Hospital, 20162 Milan, Italy.
Department of Biomedical Sciences for Health, Università degli Studi di Milano, 20133 Milan, Italy.
J Clin Med. 2023 Jul 12;12(14):4640. doi: 10.3390/jcm12144640.
Morton's neuroma (MN) is a compressive neuropathy of the common plantar digital nerve, most commonly affecting the third inter-digital space. The conservative approach is the first recommended treatment option. However, other different approaches have been proposed, offering several options of treatments, where, several degrees of efficacy and safety have been reported. We treated five consecutive patients affected by MN through three indirect ultrasound-guided injections of type I porcine collagen at weekly intervals. All patients were assessed before the treatment, after the treatment and up to 6 months after the last injection via AOFAS and VNS scores for pain, in which the function and pain were evaluated, respectively. In all patients, both analyzed variables progressively ameliorated, with benefits lasting until the last follow-up. The trend of the scores during the follow-up showed significant statistical differences. No side effects occurred. To our knowledge, this is the first study on injections of type I porcine collagen for the treatment of Morton's neuroma. Future research is needed to confirm the positive trend achieved in this MN mini-series.
Morton神经瘤（MN）是一种常见的足底趾神经压迫性神经病变，最常累及第三趾间隙。保守治疗是首先推荐的治疗选择。然而，也有人提出了其他不同的治疗方法，提供了多种治疗选择，其中已报道了不同程度的疗效和安全性。我们通过每周一次、连续三次间接超声引导下注射I型猪胶原蛋白治疗了五例连续的MN患者。所有患者在治疗前、治疗后以及最后一次注射后长达6个月时，通过AOFAS和VNS评分分别评估疼痛的功能和疼痛情况。在所有患者中，两个分析变量均逐渐改善，益处持续到最后一次随访。随访期间评分趋势显示出显著的统计学差异。未发生副作用。据我们所知，这是第一项关于注射I型猪胶原蛋白治疗Morton神经瘤的研究。需要进一步的研究来证实这个MN小系列中取得的积极趋势。
