Mahmoud Omar, Yosipovitch Gil, Attia Enas
Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, Miami Itch Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Department of Dermatology, Venereology and Andrology, Ain Shams University Hospitals, Cairo 11566, Egypt.
J Clin Med. 2023 Jul 14;12(14):4675. doi: 10.3390/jcm12144675.
Atopic dermatitis (AD) affects diverse ethnic groups with significant disparities in prevalence, disease progression, clinical outcomes, and access to care. There are limited data on AD in the Arabic population of the Middle East, yet there is a substantial economic and psychosocial burden of AD in this region with a large unmet need with regards to disease management that is critical to address. There is a trend of increasing prevalence of AD in the Arab Middle East; however, due to the large environmental, socioeconomic, and sociocultural heterogeneity of this region, prevalence varies greatly across and within countries. Similarly, clinical differences in disease presentations exist across the region, although data are limited. In this review, we will present clinical phenotypes of AD common in different regions of the Arab Middle East, and data on prevalence, genetic variations, and challenges of treatment. Further studies exploring molecular biomarkers, genetic polymorphisms, immune factors, and the microbiome of patients in the region will help to elucidate the mechanism behind ethnic differences in AD in this population as well as to understand susceptibilities and treatment response.
特应性皮炎（AD）影响着不同种族群体，在患病率、疾病进展、临床结局和获得治疗的机会方面存在显著差异。关于中东阿拉伯人群中AD的数据有限，但该地区AD的经济和心理社会负担沉重，在疾病管理方面存在大量未满足的需求，这一点至关重要。在阿拉伯中东地区，AD的患病率呈上升趋势；然而，由于该地区环境、社会经济和社会文化的巨大异质性，各国之间以及国家内部的患病率差异很大。同样，尽管数据有限，但该地区疾病表现的临床差异仍然存在。在本综述中，我们将介绍阿拉伯中东不同地区常见的AD临床表型，以及患病率、基因变异和治疗挑战的数据。进一步研究该地区患者的分子生物标志物、基因多态性、免疫因素和微生物群，将有助于阐明该人群中AD种族差异背后的机制，以及了解易感性和治疗反应。
