Rother P, Ranke T P, Ranke I
Z Alternsforsch. 1986 Jul-Aug;41(4):213-7.
The onset of ageing during childhood and adolescence is accompanied by a variety of differentiation processes, whereas ageing later in life is characterized by dysdifferentiation. One of the subjects in the present discussion is the "Dysdifferentiation hypothesis of ageing". So far differentiation has been described only in qualitative terms. The paper uses the example of hyaline cartilage development (chondrogenesis) to show that a quantitative approach to differentiation is possible, which at the same time enables random-critical study. The method used for this is stochastic geometry.
童年和青春期衰老的开始伴随着各种分化过程,而晚年的衰老则以分化异常为特征。本讨论的主题之一是“衰老的分化异常假说”。到目前为止,分化仅从定性角度进行了描述。本文以透明软骨发育(软骨形成)为例,表明可以采用定量方法来研究分化,同时这也使得进行随机临界研究成为可能。用于此目的的方法是随机几何学。