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低剂量率前列腺近距离放射治疗后老年前列腺癌患者下尿路症状的时间变化

Chronological Changes of Lower Urinary Tract Symptoms in Elderly Patients with Prostate Cancer after Low-Dose-Rate Prostate Brachytherapy.

作者信息

Tsuchiya Kunihiro, Kawase Makoto, Nakane Keita, Nakano Masahiro, Iinuma Koji, Kato Daiki, Takai Manabu, Tobisawa Yuki, Mori Takayuki, Takano Hirota, Kumano Tomoyasu, Matsuo Masayuki, Ito Takayasu, Koie Takuya

机构信息

Department of Urology, General Home Care Clinic, Gifu 5016014, Japan.

Department of Urology, Gifu University Graduate School of Medicine, Gifu 5011194, Japan.

出版信息

Life (Basel). 2023 Jul 4;13(7):1507. doi: 10.3390/life13071507.

DOI:10.3390/life13071507
PMID:37511882
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10381757/
Abstract

BACKGROUND

To compare chronological changes in lower urinary tract symptoms (LUTS) after low-dose-rate prostate extended-release therapy (LDR-BT) using the overactive bladder symptom score (OABSS) in patients aged ≥ 75 years (elderly group) versus those aged < 75 years (control group).

MATERIALS AND METHODS

Patients with prostate cancer who underwent LDR-BT at Gifu University Hospital were included in this study. The International Prostate Symptom Score (IPSS), OABSS, and quality of life-based on urinary symptoms (IPSS-QOL) were evaluated before and after LDR-BT. We compared chronological changes in IPSS, OABSS, and IPSS-QOL in the elderly group with those in the control group and assessed the association between the resolution of OABSS and clinicopathological covariates.

RESULTS

A total of 484 patients were enrolled in this study. In the elderly group, the total IPSS, OABSS, and frequency scores increased at 1 month postoperatively, whereas the control group showed an increase at 3 months postoperatively. Multivariate analysis identified changes from baseline to the maximum OABSS and pre-treatment OABSS as significant predictors of delayed resolution of OABSS after LDR-BT.

CONCLUSIONS

Changes in pre-treatment OABSS and pre- and post-LDR-BT OABSS values were independent predictors of delayed resolution of OABSS; however, no correlation was found with age.

摘要

背景

比较采用膀胱过度活动症症状评分（OABSS）评估≥75岁患者（老年组）与<75岁患者（对照组）在接受低剂量率前列腺组织间插植放疗（LDR-BT）后下尿路症状（LUTS）随时间的变化。

材料与方法

本研究纳入了在岐阜大学医院接受LDR-BT的前列腺癌患者。在LDR-BT前后评估国际前列腺症状评分（IPSS）、OABSS以及基于泌尿系统症状的生活质量（IPSS-QOL）。我们比较了老年组与对照组IPSS、OABSS和IPSS-QOL随时间的变化，并评估了OABSS缓解与临床病理协变量之间的关联。

结果

本研究共纳入484例患者。在老年组中，术后1个月时IPSS总分、OABSS及尿频评分升高，而对照组在术后3个月时出现升高。多因素分析确定从基线到最大OABSS的变化以及治疗前OABSS是LDR-BT后OABSS延迟缓解的重要预测因素。

结论

治疗前OABSS以及LDR-BT前后OABSS值的变化是OABSS延迟缓解的独立预测因素；然而，未发现与年龄相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b39/10381757/1142afb25f6a/life-13-01507-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b39/10381757/b77580114dec/life-13-01507-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b39/10381757/904615ea43fb/life-13-01507-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b39/10381757/1142afb25f6a/life-13-01507-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b39/10381757/b77580114dec/life-13-01507-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b39/10381757/904615ea43fb/life-13-01507-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b39/10381757/1142afb25f6a/life-13-01507-g003.jpg

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Radiotherapy for elder patients aged ≥80 with clinically localized prostate cancer - Brachytherapy enhanced late GU toxicity especially in elderly.对年龄≥80岁的临床局限性前列腺癌老年患者进行放射治疗——近距离放射治疗会增加晚期泌尿系统毒性，尤其是在老年患者中。
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