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脾切除术后自身免疫性溶血性贫血患者的肠系膜缺血:病例报告。

Mesenteric Ischemia in a Splenectomized Patient with Auto-Immune Hemolytic Anemia: Case Report.

机构信息

Grupo de Investigación en Salud Integral (GISI), Departamento Facultad de Salud, Universidad Santiago de Cali, Cali 5183000, Colombia.

出版信息

Medicina (Kaunas). 2023 Jul 18;59(7):1325. doi: 10.3390/medicina59071325.

DOI:10.3390/medicina59071325
PMID:37512136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10385668/
Abstract

Mesenteric ischemia is a serious complication that can occur after splenectomy for hemolytic anemia, potentially leading to lifelong intestinal problems such as ischemia and/or portal hypertension. We present the case of a 33-year-old man with a history of autoimmune hemolytic anemia and splenectomy who developed mesenteric ischemia. The patient experienced abdominal pain and diarrhea, and imaging studies revealed mesenteric vein thrombosis. Surgical intervention confirmed the diagnosis. This case significantly contributes to the existing literature by providing insights into the occurrence of mesenteric ischemia in younger individuals with predisposing factors, as well as its clinical presentation, diagnostic challenges, and severity. Moreover, it has implications for the future diagnosis and management of long-term mesenteric ischemia in patients who have undergone splenectomy for hemolytic anemia.

摘要

肠系膜缺血是一种严重的并发症,可发生于溶血性贫血脾切除术后,可能导致终身的肠道问题,如缺血和/或门静脉高压。我们报告了一例 33 岁男性,既往有自身免疫性溶血性贫血和脾切除术病史,发生肠系膜缺血。患者出现腹痛和腹泻,影像学研究显示肠系膜静脉血栓形成。手术干预证实了诊断。该病例通过提供有关有倾向因素的年轻个体中肠系膜缺血的发生、其临床表现、诊断挑战和严重程度的见解,对现有文献做出了重要贡献。此外,它对未来诊断和管理因溶血性贫血而行脾切除术的患者的长期肠系膜缺血具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18c1/10385668/526f0eb9bbfa/medicina-59-01325-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18c1/10385668/4aabe5782588/medicina-59-01325-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18c1/10385668/c5697386f947/medicina-59-01325-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18c1/10385668/526f0eb9bbfa/medicina-59-01325-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18c1/10385668/4aabe5782588/medicina-59-01325-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18c1/10385668/c5697386f947/medicina-59-01325-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18c1/10385668/526f0eb9bbfa/medicina-59-01325-g003.jpg

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本文引用的文献

1
The risk of major bleeding in patients with factor V Leiden or prothrombin G20210A gene mutation while on extended anticoagulant treatment for venous thromboembolism.因子 V 莱顿或凝血酶原 G20210A 基因突变患者在接受静脉血栓栓塞症的延长抗凝治疗时发生大出血的风险。
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Prothrombin G20210A Gene Mutation-Induced Recurrent Deep Vein Thrombosis and Pulmonary Embolism: Case Report and Literature Review.凝血酶原G20210A基因突变所致复发性深静脉血栓形成和肺栓塞:病例报告及文献复习
J Investig Med High Impact Case Rep. 2022 Jan-Dec;10:23247096211058486. doi: 10.1177/23247096211058486.
3
Mesenteric venous thrombosis presenting as gastrointestinal bleeding, a challenging diagnosis.
肠系膜静脉血栓形成表现为胃肠道出血,这是一个具有挑战性的诊断。
Am J Emerg Med. 2019 Feb;37(2):378.e1-378.e6. doi: 10.1016/j.ajem.2018.11.007. Epub 2018 Nov 7.
4
Postsplenectomy thrombosis of splenic, mesenteric, and portal vein (PST-SMPv): A single institutional series, comprehensive systematic review of a literature and suggested classification.脾切除术后脾、肠系膜和门静脉血栓形成(PST-SMPv):单机构系列、文献全面系统回顾及建议分类。
Am J Surg. 2018 Dec;216(6):1192-1204. doi: 10.1016/j.amjsurg.2018.01.073. Epub 2018 Feb 5.
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Incidence and predictors of portal and splenic vein thrombosis after pure laparoscopic splenectomy.单纯腹腔镜脾切除术后门静脉和脾静脉血栓形成的发生率及预测因素
Surgery. 2017 Dec;162(6):1219-1230. doi: 10.1016/j.surg.2017.07.016. Epub 2017 Sep 14.
6
Thromboembolic Events Following Splenectomy: Risk Factors, Prevention, Management and Outcomes.脾切除术后的血栓栓塞事件:危险因素、预防、管理及结局
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Recommendations regarding splenectomy in hereditary hemolytic anemias.遗传性溶血性贫血脾切除术的推荐意见。
Haematologica. 2017 Aug;102(8):1304-1313. doi: 10.3324/haematol.2016.161166. Epub 2017 May 26.
8
Laparoscopic splenectomy is a better surgical approach for spleen-relevant disorders: a comprehensive meta-analysis based on 15-year literatures.腹腔镜脾切除术是治疗脾脏相关疾病的更佳手术方式:基于15年文献的综合荟萃分析
Surg Endosc. 2016 Oct;30(10):4575-88. doi: 10.1007/s00464-016-4795-z. Epub 2016 Feb 19.
9
ESTES guidelines: acute mesenteric ischaemia.埃斯蒂斯指南:急性肠系膜缺血
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Splenectomy is associated with a higher risk for venous thromboembolism: A prospective cohort study.脾切除术与静脉血栓栓塞风险增加相关:一项前瞻性队列研究。
Int J Surg. 2015 Dec;24(Pt A):27-32. doi: 10.1016/j.ijsu.2015.10.011. Epub 2015 Oct 19.