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Cancer Metabolism: The Role of ROS in DNA Damage and Induction of Apoptosis in Cancer Cells.

作者信息

Zhao Yongxia, Ye Xiaochun, Xiong Zhifeng, Ihsan Awais, Ares Irma, Martínez Marta, Lopez-Torres Bernardo, Martínez-Larrañaga María-Rosa, Anadón Arturo, Wang Xu, Martínez María-Aránzazu

机构信息

National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan 430070, China.

Department of Animal Nutrition and Feed Science, Huazhong Agricultural University, Wuhan 430070, China.

出版信息

Metabolites. 2023 Jun 27;13(7):796. doi: 10.3390/metabo13070796.

DOI:10.3390/metabo13070796
PMID:37512503
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10383295/
Abstract

Cancer is a huge challenge for people worldwide. High reactive oxygen species (ROS) levels are a recognized hallmark of cancer and an important aspect of cancer treatment research. Abnormally elevated ROS levels are often attributable to alterations in cellular metabolic activities and increased oxidative stress, which affects both the development and maintenance of cancer. Moderately high levels of ROS are beneficial to maintain tumor cell genesis and development, while toxic levels of ROS have been shown to be an important force in destroying cancer cells. ROS has become an important anticancer target based on the proapoptotic effect of toxic levels of ROS. Therefore, this review summarizes the role of increased ROS in DNA damage and the apoptosis of cancer cells caused by changes in cancer cell metabolism, as well as various anticancer therapies targeting ROS generation, in order to provide references for cancer therapies based on ROS generation.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6287/10383295/9fbcbc86c1f4/metabolites-13-00796-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6287/10383295/2d78a2659d7c/metabolites-13-00796-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6287/10383295/fe319ea6edee/metabolites-13-00796-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6287/10383295/af8ea6745b60/metabolites-13-00796-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6287/10383295/9fbcbc86c1f4/metabolites-13-00796-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6287/10383295/2d78a2659d7c/metabolites-13-00796-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6287/10383295/fe319ea6edee/metabolites-13-00796-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6287/10383295/af8ea6745b60/metabolites-13-00796-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6287/10383295/9fbcbc86c1f4/metabolites-13-00796-g004.jpg

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Cancer Metabolism: The Role of ROS in DNA Damage and Induction of Apoptosis in Cancer Cells.

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本文引用的文献

[1]
Effect of photothermal and photodynamic therapy with cobalt ferrite superparamagnetic nanoparticles loaded with ICG and PpIX on cancer stem cells in MDA-MB-231 and A375 cell lines.

Photodiagnosis Photodyn Ther. 2023-9

[2]
Tailoring the Amphiphilic Structure of Zwitterionic AIE Photosensitizers to Boost Antitumor Immunity.

Adv Mater. 2023-9

[3]
Injectable cold atmospheric plasma-activated immunotherapeutic hydrogel for enhanced cancer treatment.

Biomaterials. 2023-9

[4]
The synergistic effects of PRDX5 and Nrf2 on lung cancer progression and drug resistance under oxidative stress in the zebrafish models.

Oncol Res. 2022

[5]
Survival and comorbidities in lung cancer patients: Evidence from administrative claims data in Germany.

Oncol Res. 2022

[6]
Reactive oxygen species formation and its effect on CD4 T cell-mediated inflammation.

Front Immunol. 2023

[7]
Targeting ATM and ATR for cancer therapeutics: Inhibitors in clinic.

Drug Discov Today. 2023-8

[8]
MiR-494 induces metabolic changes through G6pc targeting and modulates sorafenib response in hepatocellular carcinoma.

J Exp Clin Cancer Res. 2023-6-10

[9]
Minimally invasive injection of biomimetic Nano@Microgel for in situ ovarian cancer treatment through enhanced photodynamic reactions and photothermal combined therapy.

Mater Today Bio. 2023-5-18

[10]
Patchouli alcohol induces G /G cell cycle arrest and apoptosis in vincristine-resistant non-small cell lung cancer through ROS-mediated DNA damage.

Thorac Cancer. 2023-7

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