Andrioaie Ioana Maria, Luchian Ionut, Dămian Costin, Nichitean Giorgio, Andrese Elena Porumb, Pantilimonescu Theodor Florin, Trandabăț Bogdan, Prisacariu Liviu Jany, Budală Dana Gabriela, Dimitriu Daniela Cristina, Iancu Luminita Smaranda, Ursu Ramona Gabriela
Department and Preventive Medicine and Interdisciplinarity (IX)-Microbiology, Faculty of Medicine, "Grigore, T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Department of Periodontology, Faculty of Dental Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Pathogens. 2023 Jul 5;12(7):908. doi: 10.3390/pathogens12070908.
Human papillomavirus (HPV) is recognized as being related to a wide variety of known cancers: cervical, oropharyngeal, anal, vaginal, penile, and skin. For some of these cancers, rigorous algorithms for screening, therapeutical interventions, and follow-up procedures have been established. Vaccination using the nonvalent anti-HPV vaccine, which prevents infection regarding the most frequently involved high-risk HPV types (16, 18, 31, 33, 45, 52, and 58) and low-risk HPV types (6 and 11), has also extensively prevented, controlled, and even eradicated HPV infections. Still, even with all of these multidisciplinary interventions, the burden of HPV cancers is still high worldwide. The circulating DNA of HPV-induced cancers is thought to be an adequate biomarker for optimizing the control of these virus-related cancers. We analyzed the literature published in the last 5 years regarding ctDNA and four of the above-mentioned cancers. The most frequently used assay for ctDNA detection was the droplet digital PCR assay, used for the management of therapy in the late stages of cancer. ctDNA could not be used for early detection in any of the studied cancers. The OPSCCs were the most frequent cancers analyzed via ctDNA assays. Larger, properly designed cohort studies might establish the clinical utility of this biomarker.
人乳头瘤病毒（HPV）被认为与多种已知癌症相关：宫颈癌、口咽癌、肛门癌、阴道癌、阴茎癌和皮肤癌。对于其中一些癌症，已经建立了严格的筛查、治疗干预和随访程序算法。使用九价抗HPV疫苗进行接种，可预防最常见的高危HPV类型（16、18、31、33、45、52和58）和低危HPV类型（6和11）的感染，也广泛预防、控制甚至根除了HPV感染。然而，即便有了所有这些多学科干预措施，HPV相关癌症在全球的负担仍然很高。HPV诱导癌症的循环DNA被认为是优化这些病毒相关癌症控制的合适生物标志物。我们分析了过去5年发表的关于ctDNA和上述四种癌症的文献。最常用于检测ctDNA的方法是液滴数字PCR检测法，用于癌症晚期的治疗管理。在任何所研究的癌症中，ctDNA都不能用于早期检测。口咽鳞状细胞癌是通过ctDNA检测分析的最常见癌症。规模更大、设计合理的队列研究可能会确定这种生物标志物的临床应用价值。
