艾沙康唑与两性霉素B联合对毛霉目真菌的体外活性
In Vitro Activity of Isavuconazole and Amphotericin B in Association against Mucorales.
作者信息
Ortalli Gaia, Oliva Ester, Lo Cascio Giuliana, Farina Claudio
机构信息
Microbiology and Virology Laboratory, ASST "Papa Giovanni XXIII", Piazza OMS 1, 24127 Bergamo, Italy.
Microbiology and Virology Laboratory, Ospedale Guglielmo da Saliceto, Via Taverna 49, 29121 Piacenza, Italy.
出版信息
Pathogens. 2023 Jul 18;12(7):948. doi: 10.3390/pathogens12070948.
Abstract
Mucormycoses can be treated with the combination of Amphotericin B and Isavuconazole. This study evaluates the effects of these drugs in vitro against 59 strains representing 12 Mucorales. In vitro testing of the two drugs together and alone was performed using the MIC " synergy-method" (ETSM), which is more standard in clinical practice than microbroth dilution testing. Amphotericin B and Isavuconazole have synergistic/additive effects against , and . Different effects have been shown for other Mucorales. ETSM can help the clinical management of mucormycosis from a practical point of view, due to its feasibility in the laboratory.
摘要
毛霉病可用两性霉素B和艾沙康唑联合治疗。本研究评估了这两种药物在体外对代表12个毛霉目属的59个菌株的作用。使用最低抑菌浓度“协同方法”（ETSM）对这两种药物进行单独和联合的体外测试，该方法在临床实践中比微量肉汤稀释测试更具规范性。两性霉素B和艾沙康唑对 、 和 具有协同/相加作用。对其他毛霉目属显示出不同的作用。由于ETSM在实验室中的可行性，从实际角度来看，它有助于毛霉病的临床管理。
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