Upton L G
Oral Surg Oral Med Oral Pathol. 1979 Jun;47(6):513-4. doi: 10.1016/0030-4220(79)90272-x.
Current pain concepts suggest a dual role in pain perception. Both motivational, effective, and somatosensory components are noted. Pain affects the patient's psyche and, conversely, the patient's state of mind modifies pain perception. Consequently, it might be expected that a sedative/analgesic combination might be more effective than either the sedative or the analgesic alone in controlling pain. A clinical study was carried out to compare a promethazine-A.P.C. combination with promethazine and A.P.C. alone. One hundred forty-nine patients undergoing third molar removal were studied, with each patient serving as his own control. The results indicated a significant difference between the promethazine-A.P.C. combination and prometazine alone or Phenergan alone. No significant difference was noted between the promethazine-A.P.C. combination and A.P.C. alone.
当前的疼痛概念表明在疼痛感知中存在双重作用。动机、情感和躯体感觉成分均被提及。疼痛会影响患者的心理，反之，患者的心理状态也会改变疼痛感知。因此，可以预期在控制疼痛方面，镇静/镇痛联合用药可能比单独使用镇静剂或镇痛药更有效。进行了一项临床研究，比较异丙嗪 - 阿司匹林复合制剂与单独使用异丙嗪和阿司匹林的效果。对149名接受第三磨牙拔除术的患者进行了研究，每位患者自身作为对照。结果表明，异丙嗪 - 阿司匹林复合制剂与单独使用异丙嗪或单独使用非那根之间存在显著差异。而异丙嗪 - 阿司匹林复合制剂与单独使用阿司匹林之间未发现显著差异。
