Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Nuh Naci Yazgan University, Kayseri, Turkey.
Department of Periodontology, Faculty of Dentistry, Nuh Naci Yazgan University, Kayseri, Turkey.
Lasers Med Sci. 2023 Jul 29;38(1):169. doi: 10.1007/s10103-023-03834-x.
The inferior alveolar nerve can be damaged during dental procedures, leading to symptoms, such as tingling, numbness, and reduced quality of life. Recovery depends on factors such as medications, surgery, and photobiomodulation therapy. Photobiomodulation therapy has shown the potential to improve nerve function and reduce regeneration time; however, there is no standard treatment protocol yet. This study aimed to examine the effect of diode lasers on nerve regeneration in patients with axonetmesis injuries. In this experiment on animals, Wistar rats' damaged sensory systems were treated with lasers to restore them. Animals were randomly divided into six groups: a sham group, a control group, and four laser treatment groups(1st group: performed every day, 10 sessions; 2nd group: performed every 2 days, 10 sessions; 3rd group: performed every day, 20 sessions; and 4th group: performed every 2 days, 20 sessions). Sensory function was determined using the Semmes-Weinstein monofilament test, which was repeated after the surgical procedure. The results showed that the 20-session group had the best improvement, most closely resembling the group without sensory test damage. The histomorphometric results showed that the number of axons was significantly lower in the group that received 10 daily sessions and in the control group than in the undamaged nerve. Axon diameter was lower in all groups than in the sham group. In conclusion, the remarkable aspect of this study is that consecutive-day 20-session laser treatment showed better improvement than the over-the-day 20-session treatment protocol.
下牙槽神经在牙科手术过程中可能会受到损伤，导致刺痛、麻木和生活质量下降等症状。恢复情况取决于药物、手术和光生物调节疗法等因素。光生物调节疗法已显示出改善神经功能和减少再生时间的潜力；然而，目前还没有标准的治疗方案。本研究旨在探讨二极管激光对轴索断裂损伤患者神经再生的影响。在这项动物实验中，使用激光治疗 Wistar 大鼠受损的感觉系统以恢复其功能。动物随机分为六组：假手术组、对照组和四组激光治疗组（第 1 组：每天治疗 10 次；第 2 组：每两天治疗 10 次；第 3 组：每天治疗 20 次；第 4 组：每两天治疗 20 次）。使用 Semmes-Weinstein 单丝试验测定感觉功能，术后重复测定。结果显示，20 次治疗组的改善效果最佳，与无感觉测试损伤组最为相似。组织形态计量学结果显示，每天接受 10 次治疗和对照组的轴突数量明显低于未受损神经。所有组的轴突直径均低于假手术组。综上所述，本研究的显著特点是连续 20 次治疗日的激光治疗比隔日 20 次治疗方案的改善效果更好。
