Nieminen P
Acta Pathol Microbiol Immunol Scand C. 1986 Jun;94(3):119-25. doi: 10.1111/j.1699-0463.1986.tb02100.x.
The distribution of NK-9 antigen presenting cells in human lymphoid tissues including spleen, tonsil, lymph node, and thymus was studied. The staining were done on formalin-fixed, histological sections. In peripheral blood NK-9 antigens are expressed on allospecific (CTL) and nonspecific (NK and AK) cytotoxic lymphocytes. In lymphoid tissues, the distribution of NK-9 positive cells was definitely different from "normal" T cell distribution, measured by pan T monoclonal markers. In tonsils and lymph nodes NK-9 positive cells were mainly located in and around germinal centers. However, only a proportion of these areas were NK-9 positive. In spleen NK-9 positive cells were located mainly in periarteriolar lymphocyte sheats and in germinal centers. Thymuses were practically NK-9 negative. These results support the earlier suggestions that cytotoxic cells take part in the immunoregulation in lymphoid tissues.
研究了NK-9抗原呈递细胞在人脾、扁桃体、淋巴结和胸腺等淋巴组织中的分布。在福尔马林固定的组织学切片上进行染色。在外周血中，NK-9抗原在同种特异性（CTL）和非特异性（NK和AK）细胞毒性淋巴细胞上表达。在淋巴组织中，通过泛T单克隆标志物检测，NK-9阳性细胞的分布与“正常”T细胞分布明显不同。在扁桃体和淋巴结中，NK-9阳性细胞主要位于生发中心及其周围。然而，这些区域中只有一部分是NK-9阳性的。在脾脏中，NK-9阳性细胞主要位于动脉周围淋巴细胞鞘和生发中心。胸腺实际上是NK-9阴性的。这些结果支持了早期的观点，即细胞毒性细胞参与淋巴组织中的免疫调节。
