Tárnoky K, Szenohradszky J, Petri G
Acta Physiol Hung. 1986;67(4):447-56.
In experiments on dogs, the spontaneous movements of the small bowel were in all cases enhanced by the alpha 2-blocker phentolamine, while they were not influenced, or were slightly decreased, by the beta 1-blocker practolol. Neither drug caused a change in the noradrenaline content of the intestinal wall. In the same animals, the joint administration of phentolamine and practolol led to a considerable increased small bowel motility, and to a significant decrease in the noradrenaline level of the intestinal wall. The results are in agreement with experimental data indicating that presynaptic alpha-receptors play a primary role in the sympathetic regulation of small bowel motility.
在对狗的实验中，α₂受体阻滞剂酚妥拉明在所有情况下均增强了小肠的自发运动，而β₁受体阻滞剂普拉洛尔对其无影响或使其略有降低。两种药物均未引起肠壁去甲肾上腺素含量的变化。在同一批动物中，酚妥拉明和普拉洛尔联合给药导致小肠运动显著增强，且肠壁去甲肾上腺素水平显著降低。这些结果与实验数据一致，表明突触前α受体在小肠运动的交感神经调节中起主要作用。
